The Cleveland Clinic Foundation

University of California

University of Michigan

Other

Vanderbilt University

Shuvo Roy

Aaron J Fleischman

Rishi Kant

Kenneth G Goldman

Benjamin W Chui

Nathan Wright

William H Fissell

Steven G Goebel

Edward C Benzel

Charles Blaha

Lisa Ferrara

Andrew Posselt

William Fissell

Shang Song

Amanda Buck

Mark Goodin

Willieford Moses

Joey Groszek

James R Talman

H David Humes

Hilel Lewis

Torin Yeager

William H Fissell, Iv

Emily Abada

Ajay S Dharia

Brian L Sauer

Vivek Subramanian

Michel Martin Maharbiz

Michael Richard Harrison

Daniel A Cohen

Elisabeth Jacques Leeflang

Maciej Zborowski

Jeff Chalmers

Ana Claudia Arias

Kenneth Ouriel

David M Young

Yasser Khan

Monica Lin

Geoffrey R Lockwood

Albert Terrence Conlisk

Sarah Swisher

Amy Liao

Felippe Pavinatto

Subhra Datta

Aoron J Fleischman

Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.

Hemofilter for in vivo blood filtration

Filtration membrane with improved mechanical stability and increased resistance to pressure is provided. The filtration membrane is useful for in vivo implantable filtration devices, such as, an artificial kidney. In vivo implantable filtration devices are also provided.

In vivo blood filtration membranes and devices

Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

Hemofiltration device and methods of use thereof

Bioartificial ultrafiltration devices comprising a scaffold comprising a population of cells enclosed in a matrix and disposed adjacent a plurality of channels are provided. The population of cells provides molecules such as therapeutic molecules to a subject in need thereof and is supported by the nutrients filtered in an ultrafiltrate from the blood of the subject. The plurality of channels in the scaffold facilitate the transportation of the ultrafiltrate and exchange of molecules between the ultrafiltrate and the population of cells.

Bioartificial ultrafiltration device and methods related thereto

Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.

Gas exchange composite membranes and methods of use thereof

The present technology provides micro fabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.

Low resistance microfabricated filter

The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.

Ultrafiltration membrane, device, bioartificial organ, and related methods

Growing community of inventors

Cleveland, OH, United States of America

Shuvo Roy