University of Southern California

Biovinc LLC

University of California

Massachusetts Eye and Ear Infirmary

Shuting Sun

Charles E McKenna

Frank Hallock Ebetino

Keivan Sadrerafi

Mark Walden Lundy

Albert Edge

Michael J McKenna

Boris A Kashemirov

William Sewell

Judith Kempfle

Ichiro Nishimura

Eric T Richard

Akishige Hokugo

Philip T Cherian

Woo Seok Kang

Kim Nguyen

David Jung

Parish Sedghizadeh

Philip Cherian

Charles E Mckenna

This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

Phosphonate-drug conjugates

Described herein are bisphosphonate oxazolidinone compounds, and conjugates and pharmaceutical formulations thereof, that can include a bisphosphonate and an oxazolidinone (or an oxazolidinone antimicrobial or antibiotic agent, substituent or derivative thereof), where the oxazolidinone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate oxazolidinone compounds, conjugates and pharmaceutical formulations thereof. Also provided herein are methods of use of the compounds, conjugates and formulations for treating a bone disease or for use in preparing a formulation for the treatment a bone disease.

Bone targeted antimicrobial oxazolidinone related compounds, formulations thereof, and uses thereof

Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.

Bisphosphonate quinolone conjugates and uses thereof

Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.

Skeletal removal of bisphosphonates

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Temple City, CA, United States of America

Shuting Sun