Nichiban Company Limited

Shuta Nakanami

Takao Hiraoka

Toru Koga

Kanako Inagaki

To provide a packaging for a rivastigmine-containing adhesive patch having excellent temporal stability of rivastigmine, an adhesive patch product including the adhesive patch and a packaging bag, and a method for manufacturing the same. An adhesive patch product including a packaging bag formed from a laminate of at least three layers including an ethylene-vinyl alcohol copolymer film and a rivastigmine-containing adhesive patch housed in the packaging bag and having a residual oxygen concentration of 10% by volume or less in the packaging bag, and a method for manufacturing the same are provided. In addition, a packaging for a rivastigmine-containing adhesive patch formed from a laminate including an ethylene-vinyl alcohol copolymer film and having a residual oxygen concentration of 10% by volume or less therein is provided.

Packaging for adhesive patch containing rivastigmine

A transdermal patch for the treatment of Alzheimer's disease includes: a backing, a rivastigmine-containing layer, a pressure-sensitive adhesive layer, and a release liner. In the transdermal patch, the rivastigmine-containing layer contains rivastigmine and an alkyl(meth)acrylate resin, the pressure-sensitive adhesive layer is composed of an acrylic pressure-sensitive adhesive containing a (meth)acrylic acid ester having a hydroxyl group, and neither the rivastigmine-containing layer nor the pressure-sensitive adhesive layer contains an anti-oxidizing agent.

Transdermal patch

A transdermal patch for the treatment of Alzheimer's disease includes: a backing, a rivastigmine-containing layer, a pressure-sensitive adhesive layer, and a release liner. In the transdermal patch, the rivastigmine-containing layer contains rivastigmine and an alkyl (meth)acrylate resin, the pressure-sensitive adhesive layer is composed of an acrylic pressure-sensitive adhesive containing a (meth)acrylic acid ester having a hydroxy group, and neither the rivastigmine-containing layer nor the pressure-sensitive adhesive layer contains an anti-oxidizing agent.

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Bunkyo-ku, Japan

Shuta Nakanami