Sunshine Lake Pharma Co., Ltd.

Shushan Lin

Yu Meng Li

Chao Chen

Liang Liu

Zheng Fu

Xiaofeng Chen

Wenjia Li

Yu Li

Provided is a fusion protein containing GLP-1 and FGF21 linked through an immunoglobulin Fc portion. Each of the GLP-1 and FGF21 can be substituted with its analogues or variants and, the Fc portion, which can be derived from IgG4, can include substitutions that further enhance the fusion protein's stability and activity. These fragments can be linked together through peptide linkers. The fusion protein can be used clinically to reduce glucose and lipid levels and body weight.

Dual-target fusion proteins comprising FGF21 and GLP-1, connected through a Fc portion of an immunoglobulin

A fibroblast growth factor 21 (FGF21) variant, further to a FGF21 variant fusion protein, a protein multimer, and use thereof can significantly improve the binding ability with the target and can be used to treat metabolic diseases.

FGF21 variant, fusion protein and application thereof

Growing community of inventors

Dongguan, China

Shushan Lin