Texas Biotechnology Corporation

Encysive Pharmaceuticals, Inc.

Shuqun Lin

Ronald J Biediger

Bore G Raju

Robert V Market

Ian Leslie Scott

Jamal M Kassir

Vanessa O Grabbe

George W Holland

Chengde Wu

Timothy P Kogan

Karin M Keller

Timothy P Kogan, Deceased

Raju G Bore

Timothy P Di Kogan

A method for the inhibition of the binding of &agr;,&bgr;,integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions thereof; and the use of the compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;,&bgr;,is involved.

Compounds that inhibit the binding of integrins to their receptors

A method for the inhibition of the binding of &agr;,&bgr;,integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;,&bgr;,is involved.

N, N-disubstituted amides that inhibit the binding of integrins to their receptors

A method for the inhibition of the binding of .alpha..sub.4 .beta..sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha..sub.4 .beta..sub.1 is involved.

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Huntingdon Valley, PA, United States of America

Shuqun Lin