California Institute of Technology

Duke University

Shuo Pang

Changhuei Yang

Guoan Zheng

Jigang Wu

Seung Ah Lee

Benjamin Judkewitz

Samuel Yang

David Brady

Ying Min Wang

Joel Alter Greenberg

Kenneth Patrick MacCabe

Zheng Li

An imaging system operative for providing a volumetric molecular image of an object is disclosed. The imaging system interrogates the object with structured x-ray radiation while continuous relative motion between the object and source is induced during a measurement period. As the radiation passes through the object, the radiation scatters based on the molecular composition within the object, and the scattering changes as a function of time due to the relative motion between the source and object. Coherent scatter radiation is detected and processed to reconstruct an estimate of the three-dimensional molecular structure of the object using a reconstruction algorithm, such as maximum likelihood estimation.

Volumetric-molecular-imaging system and method therefor

An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the specimen surface. The sub-pixel shifted projection images associated with light from a plurality of illumination angles provided by an illumination source.

e-Petri dishes, devices, and systems having a light detector for sampling a sequence of sub-pixel shifted projection images

Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris.

Methods for rapid distinction between debris and growing cells

A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.

Light guided pixel configured for emissions detection and comprising a guide layer with a wavelength selective filter material and a light detector layer

Talbot imaging systems comprising a Talbot element, a phase gradient generating device, a light detector, and a processor. The Talbot element repeats a Talbot image at a distance from the Talbot element. The phase gradient generating device scans the Talbot image at a plane at the distance from the Talbot element by incrementally changing a phase gradient of a light field incident the Talbot element. As the Talbot image is scanned, the light detector captures time varying data associated with light altered by an object located at the distance from the Talbot element. The processor reconstructs an image of the object based on the time-varying light data.

Talbot imaging devices and systems

A Talbot-illuminated imaging system for focal plane tuning, the device comprising a Talbot element, a tunable illumination source, a scanning mechanism, a light detector, and a processor. The element generate san array of focused light spots at a focal plane. The tunable illumination source shifts the focal plane to a plane of interest by adjusting a wavelength of light incident the Talbot element. The scanning mechanism scans an object across an array of focused light spots in a scanning direction. The light detector determines time-varying light data associated with the array of focused light spots as the object scans across the array of light spots. The processor constructs an image of the object based on the time-varying data.

Talbot-illuminated imaging devices, systems, and methods for focal plane tuning

Embodiments of the present invention relate to holographically illuminated imaging devices including a holographic element for transforming an illumination beam into a focal array of light spots, a scanning mechanism for moving an object across one or more light spots in the focal array of light spots, and a light detector for detecting light associated with the focal array of light spots and generating light data associated with the received light.

Holographically illuminated imaging devices

Embodiments of the present invention relate to a reflective focusing and transmissive projection device having a body, a set of reflective-focusing components and a light detector. The body has a surface layer with first and second surfaces, and a detecting layer outside the second surface. The set of reflective-focusing components is in the surface layer. Each reflective-focusing component has a contouring element and a curved reflective element conformed to the contouring element. The curved reflective element is configured to reflect light of a first type, transmit light of a second type and focus the light of the first type outside the first surface of the surface layer. The light detector is in the detecting layer, and is configured to receive light and generate light data associated with the received light. Also, the contouring element can be configured to focus the light of the second type on the light detector.

Reflective focusing and transmissive projection device

Embodiments of the present invention relate to a delayed emission detection device comprising a time-gated illumination source configured to provide excitation light to fluorophore during an excitation period and a light detector configured to receive emissions released from the fluorophore during a collection period after the excitation period.

Growing community of inventors

Pasadena, CA, United States of America

Shuo Pang