Eisai R&d Management Co., Ltd.

Shuntaro Arase

Yuta Suzuki

Yosuke Ueki

Yasuhiro Zaima

Kanta Horie

Seiji Takemoto

Futoshi Shikata

Kentaro Nagane

Shusuke Sano

Kazuo Kazama

Disclosed is a pharmaceutical composition comprising a lipid complex, wherein the lipid complex comprises a double-stranded ribonucleic acid comprising a sense strand consisting of a nucleotide sequence set forth in SEQ ID NO: 145 and an antisense strand consisting of a nucleotide sequence set forth in SEQ ID NO: 146, and a pH of a solution of the lipid complex is 5.0 or less, or 7.5 or more.

Pharmaceutical composition containing double-stranded ribonucleic acid inhibiting expression of complement C5

The present invention provides a pharmaceutical composition comprising a compound represented by formula (1): or N-[3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d] [1,3]thiazin-7a-yl)-4-fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide, or a pharmaceutically acceptable salt of the foregoing, and a salt of a compound having a C12-22 saturated aliphatic hydrocarbon group.

Pharmaceutical composition of fused aminodihydrothiazine derivative

Growing community of inventors

Gifu, Japan

Shuntaro Arase