Kao Corporation

Kanebo, Limited

Kanebo Cosmetics Inc.

Shunsuke Yamazaki

Takeshi Ikemoto

Shintaro Inoue

Masaki Yoshida

Akinori Haratake

Hiroko Nakatsugawa

Hideyo Uchiwa

Mariko Hara

Sachiyo Hirotsu

Junichi Matsui

Tomohiro Yokota

Motoi Hayase

A skin cosmetic composition comprising the compound represented by the following formula (1): wherein Ris hydrogen and Ris hydrogen or glucose residue.

Dihydroxyphenyl compounds and glucoside compounds thereof

The present invention provides a method for enhancing epidermal permeability barrier function of the aged skin, which includes the step of externally administering to the aged skin an amount of a fumaric acid diester derivative expressed by the following general formula (1) as an active ingredient wherein Rrepresents a Calkylene group; Rand Reach represents a linear or branched Calkyl group; and n is an integer of 2 to 5.

Skin external agents and drugs

Skin external agent compositions and drugs characterized by containing fumaric acid diester derivatives represented by following general formula (1), wherein Rrepresents Calkylene; Rand Rrepresent each liner or branched Calkyl; and n is an integer of 2 to 5; which provide epidermal barrier function potentiating agents and skin external agent compositions having a high safety, quickly relieving epidermal permeation barrier function failures and having an effect of maintaining the skin in a cosmetologically healthy state; agents to be used together with HB-EFG expression inducing agents accelerating epidermal turnover, amphiregulin expression inhibitors regulating excessive epidermal proliferation, and retinoic acid or its derivative preventing skin chapping caused by retinoic acid or its derivative; and skin aging relieving agents capable of ameliorating depression in the skin metabolism and thinning in association with aging.

The present invention is a compound represented by the following formula (1) or (2):where one of Rand Ris hydrogen and the other one is hydrogen or glucose residue. The compound is effective for reforming obese constitution, suppressing or preventing obesity. It is also effective for skin whitening.

Growing community of inventors

Odawara, Japan

Shunsuke Yamazaki