Amgen Inc.

Shunsuke Takenaka

Ian Nevin Foltz

Gunasekaran Kannan

Zhulun Wang

Neeraj Jagdish Agrawal

Marissa Mock

Khaled M K Z Ali

Darren L Bates

Daren Bates

Ian Foltz

Khaled MKZ Ali

Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.

Interleukin-21 mutein/ anti-PD-1 antibody conjugates

Provided herein are PD-1 antigen-binding proteins and related nucleic acids, vectors, host cells, kits and pharmaceutical compositions. Methods of making PD-1 antigen-binding proteins and methods of treating a subject are further provided.

Anti-PD-1 antibodies and methods of treatment

Growing community of inventors

Thousand Oaks, CA, United States of America

Shunsuke Takenaka