Ajinomoto Co., Ltd.

Ea Pharma Co., Ltd.

Shunsuke Kageyama

Misato Noguchi

Masayuki Sugiki

Yoichiro Shima

Itsuya Tanabe

Toshihiko Sugiura

Ayatoshi Andou

Takashi Yamamoto

Akira Nakayama

Tamotsu Suzuki

Yasuhiro Tanaka

Tatsuya Okuzumi

Tadakiyo Nakagawa

Munetaka Tokumasu

Noriyasu Kataoka

Kazuyuki Sagi

Tatsuhiro Yamada

Koichi Fujita

Hajime Ito

Yoriko Yamamoto

Kenji Shinkai

Ryohei Yokoyama

Kazuyuki Ubukata

Agung Eviryanti

Hiroshi Yamamoto

Naoyuki Fukuchi

Morikazu Kito

Takashi Kayahara

Kanna Kuribayashi

Ayatoshi Ando

Shunsuke Fukuda

Hirokazu Ueno

Tomoko Miyazawa

Masatsugu Noguchi

Nobuhiko Hayakawa

Yoshiki Goda

Hiroyuki Eda

Aya Kirihara

Tarou Nakamura

Manami Shuto

Mizuki Dohi

Ryuta Takashita

Provided is a pharmaceutical composition for treating ulcerative colitis, comprising a compound represented by a formula (1) or a pharmaceutically acceptable salt thereof, wherein the compound or the pharmaceutically acceptable salt is administered in an amount of 600 mg or more per day to an ulcerative colitis patient. 

Pharmaceutical composition for treating ulcerative colitis

Sulfonamide compounds of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent &#x3b1;4 integrin-inhibitory action. The compounds have formulae represented by: 

Sulfonamide derivative and medicinal use thereof

The present invention has searched for a variety of compounds which show IL-12/IL-23 production-inhibitory activities and herein provides a pharmaceutical composition and an agent for preventing or treating IL-12/IL-23 excess production-related diseases, which comprise the compound.

Pyrazolo-pyrimidine compounds

Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin.

Phenylalanine derivatives

It is provided a method for producing a subunit peptide originating from an oligomeric protein having disulfide bonds within a subunit and between subunits. The method comprises producing a subunit originating from an oligomeric protein having disulfide bonds within a subunit and between subunits by the following steps:

Process for producing subunit peptide originating in polymer protein

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Kawasaki, Japan

Shunsuke Kageyama