Shiseido Company, Limited

Shunsuke Iriyama

Satoshi Amano

Hirotada Fukunishi

Masaru Suetsugu

Shinji Inomata

Kenichi Umishio

Makoto Tsunenaga

Eijiro Adachi

Jiro Kishimoto

Tsutomu Soma

Shigeyoshi Fujiwara

Takuya Hiruma

Yumiko Ishimatsu

Ken Kusakari

Yukiko Matsunaga

Saori Tanno

Provided is a screening method for a laminin 511 expression promoter, which takes the expression of laminin 511 as an indicator. Also provided is an agent for improving skin barrier function, elasticity, hydration and inflammation. This agent includes at least one extract selected from among a group consisting of brown algae, red algae and green algae.

Screening method for laminin 511 production promoting agent, basal epidermal layer stabilizing agent, and/or epidermal stem cells reduction inhibiting or proliferation promoting agent

The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.

Artificial skin

A heparanase activity inhibitor containing, as an active ingredient, a 4-alkylresorcinol represented by formula (I): wherein R represents a C1-6 linear or branched alkyl group.

Heparanase activity inhibitor, wrinkle improving agent containing same, and pharmaceutical composition

A heparanase activity inhibitor comprising, as an active ingredient, a cyclic carboxamide derivative represented by formula (I): wherein n is an integer of 1 to 3, Ris hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl, X is &#x2014;CH&#x2014; or a group represented by &#x2014;N(R)&#x2014;, and Ris hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl,or a salt thereof.

Heparanase activity inhibitor

Disclosed is a cell transformed by a vector containing human Wnt3a gene, wherein the cell is selected from a group consisting of hair follicle-derived cells and prostate cancer-derived cells.

Cell transformed by human Wnt3a gene

Growing community of inventors

Yokohama, Japan

Shunsuke Iriyama