Nissan Chemical Industries Limited

Sucampo Ag

R-tech Ueno, Ltd.

Shunsuke Fukuya

Ryuji Ueno

Manabu Yaosaka

Takashi Mizukoshi

Tatsuya Matsukawa

Yuji Moriyama

Hiroyuki Kousaka

Noriyuki Yamamoto

Michiharu Handa

Katsuya Sakata

Hiroyuki Kotajima

A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Zis wherein R3 is a protecting group for a hydroxy group;which includes the step of reacting a compound of formula (II): wherein Zis the same as Zexcept for when Zis Zis with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.

Method for preparing a fatty acid derivative

A production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) where X is a halogen atom, Chaloalkyl, etc., Y is a halogen atom, Calkyl, etc., Ris a Chaloalkyl, etc., Rand Rindependently of each other are a hydrogen atom, Calkyl, etc., Ris Calkyl, Chaloalkyl, etc., Ris a hydrogen atom, calkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, including: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, &#x2014;C(O)OH, &#x2014;C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R, R, R, and Rare the same as defined above, or a salt thereof; crystal forms and the production method thereof. 

Production method of isoxazoline-substituted benzoic acid amide compound

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Sanyoonoda, Japan

Shunsuke Fukuya