Sankyo Company, Limited

Shunshi Kojima

Rei Okazaki

Mitsugi Shibano

Hideharu Yokokawa

Mutsuo Suzuki

Mutsauo Suzuki

A method for producing highly pure enamines, which comprises reacting an aldehyde or ketone with an amine and treating the resulting reaction mixture with an acidic aqueous solution at a temperature between 0&#xb0; C. and 30&#xb0; C.

Process for production of high-purity enamines

A process for the production of a &#x3b3;-ketoacetal compound wherein the desired product is obtained by a simple procedure in a high yield as a high purity product. The reaction scheme for the process is as follows: wherein Ar is an aryl group; X is a halogen atom; Rand Ris an alkyl or alkoxy group; and

Process for the production of &#x3b3;-keto acetals

An intermediate useful in the synthesis of milbemycin derivatives having an ether bond at the 13-position and which is represented by the general formula (IIId): ##STR1## wherein R represents a methyl group, an ethyl group, an isopropyl group or a sec-butyl group, and R.sup.5 and R.sup.6' each individually represents a hydrogen atom or a protecting group, and related precursors as well as to a process for producing these intermediates.

Processes for the production of 13-ether derivatives of milbemycins and

An intermediate useful in the synthesis of milbemycin derivatives having an ether bond at the 13-position and which is represented by the general formula (IIId): ##STR1## wherein R represents a methyl group, an ethyl group, an isopropyl group or a sec-butyl group, and R.sup.5 and R.sup.6' each individually represents a hydrogen atom or a protecting group,

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Kamakura, Japan

Shunshi Kojima