Takeda Chemical Industries, Inc.

Takeda Chemical Company, Ltd.

Shunsaku Noguchi

Kiyohisa Kawai

Yoshiaki Araki

Tetsuya Aono

Yasuhiko Kawano

Saburo Takei

Masayuki Imanishi

Spiro[cyclopropane-1,2'-indolin]-3'-ones of the general formula: ##STR1## wherein the ring A is a substituted or unsubstituted phenyl ring and Z is hydrogen, a substituted or unsubstituted alkyl group or a substituted or unsubstituted acyl group and their pharmaceutically acceptable salts have gastric acid secretion suppressing activity, antiinflammatory activity and analgesic activity.

Spiro[cyclopropane-1,2'-indolin]-3'-ones

Compounds of the formula: ##STR1## WHEREIN R.sup.1 is an aryl group which may be substituted, R.sup.2 is hydrogen or a lower alkyl group having 1 to 4 carbon atoms and n is 1 or 2, or derivatives at the carboxyl function thereof, are useful as medicines such as antipyretics, analgesics and anti-inflammatory agents.

Benzalicyclic carboxylic acid derivative

A novel indan-1-carboxamide derivative of the formula ##STR1## wherein X represents hydrogen or a halogen; R.sub.1 represents hydrogen, a lower alkyl group which may be substituted with hydroxyl group or represents phenyl group; and R.sub.2 represents a lower alkyl group which may be substituted with hydroxyl, phenyl or an N,N-dilower-alkylamino group, or represents hydroxyl group, an amino group which may be substituted with a mono- or di-lower alkyl group, phenyl group or with a halophenyl group, or represents a phenyl group which may be substituted with a halogen or a mono- or di-lower alkyl group, a lower alkoxyl group or with sulfamoyl group; or R.sub.1 and R.sub.2, together with the adjacent nitrogen atom, form a piperidino group, a morpholino group or a piperazino group which may be substituted with a lower alkyl group on the 4-positioned nitrogen atom, which compounds are useful as medicines, for example, analgesic, anti-inflammatory, anti-pyretic or anti-rheumatic agents.

6-Halo-5-cyclohexylindan-1-carbohydroxamic acid

Compounds of the formula: ##STR1## wherein R.sup.1 is an aryl group which may be substituted, R.sup.2 is hydrogen or a lower alkyl group having 1 to 4 carbon atoms and n is 1 or 2, or derivatives at the carboxyl function thereof, are useful as medicines such as antipyretics, analgesics and anti-inflammatory agents.

4-Benzoylindan-1-carboxamide and derivatives thereof

Compounds of the formula: ##SPC1## Wherein R.sup.1 is an aryl group which may be substituted, R.sup.2 is hydrogen or a lower alkyl group having 1 to 4 carbon atoms and n is 1 or 2, or derivatives at the carboxyl function thereof, are useful as medicines such as antipyretics, analgesics and anti-inflammatory agents.

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Osaka, Japan

Shunsaku Noguchi