Ekos Corporation

Other

Meiji Seika Kaisha, Ltd.

Shunro Tachibana

Sumitomo Electric Industries, Limited

Sonopore, Ltd.

Katsuro Tachibana

Uichi Shibata

Gary Lichttenegger

James R Anderson

Ichiro Sogawa

Disclosed is a sonic fine-hole forming apparatus for forming a fine-hole in a surface of a membrane or solid body in a liquid by means of sonic energy. The sonic fine-hole forming apparatus is adapted to generate a sonic oscillation driving signal comprises a voltage waveform which has positive and negative voltage portions being asymmetrical, and a sharp peak portion. The sonic fine-hole forming apparatus includes a sonic oscillation section having a surface provided with a covering layer or a protective material having an electrically insulating property and a sonic transparency. The coated layer or a protective material is formed to have a thickness of 10 &#x3bc;m or more. The sonic fine-hole forming apparatus of the present invention can form a fine-hole in a surface of a solid body without using a large-scale apparatus, while suppressing a destructive action around the fine-hole.

Sonic fine-hole forming apparatus

A booster comprising a plurality of microbubbles of a gas in a liquid, e.g. about 4&times;10 cells/ml of microbubbles of a gas having a diameter of 0.1. to 100 &mgr;m in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.

Booster for therapy of disease with ultrasound and pharmaceutical IDLIQU composition containing the same

A kit and method for causing tissue death within a tissue site is disclosed. The kit includes a media with a light activated drug activatable upon exposure to a particular level of ultrasound energy. The kit also includes a catheter with a lumen coupled with a media delivery port through which the light activated drug can be locally delivered to the tissue site. The ultrasound transducer is configured to transmit the level of ultrasound energy which activates the light activated drug with sufficient power that the ultrasound energy can penetrate the tissue site.

Ultrasound assembly for use with light activated drugs

An apparatus for creating holes in a biological tissue is disclosed. The apparatus includes a housing which at least partially defines a fluid chamber. The fluid chamber including a tissue contact surface which is configured to be positioned adjacent the biological tissue. An ultrasound delivery device is positioned adjacent the fluid chamber and is configured to cavitate a fluid within the fluid chamber. A plurality of apertures extend from the fluid chamber through the tissue contact surface. The apertures are sized to permit passage of the cavitated fluid through the apertures.

Apparatus for transport of fluids across, into or from biological tissues

A remedial ultrasonic wave generating apparatus which allows highly efficient dispensation of a medicine without complicated preparations is provided. An ultrasonic wave generating apparatus for supplying an ultrasonic wave signal to a remedial ultrasonic oscillation element comprising an ultrasonic wave signal generating for generating an ultrasonic wave signal whose frequency randomly changes. The ultrasonic wave signal generating is constituted by, for example, a plurality of oscillation circuits oscillating at different frequencies and a switching circuit for randomly selecting one of the outputs of these oscillation circuits based on the output of a random number generating circuit.

Remedial ultrasonic wave generating apparatus

A sheet for measuring ultrasonic waves with which it is possible to easily measure a 2-dimensional ultrasonic wave distribution comprises a fluid in which multiple bubbles, each consisting of a minute quantity of gas covered by an extremely thin covering, are dispersed and sealed in a transparent baglike sheet.

Sheet for measuring ultrasonic waves

A medicine applying tool is provided at the tip of a catheter that is used to inject the medicine. An electrode portion has first and second electrodes that are provided so that they interpose a piezoelectric element therebetween. An opening is provided in the vicinity of the electrode portion, and serves to inject a medicine supplied through the catheter into a patient. A third electrode is electrically connected to the patient. An electric signal of an ultrasonic frequency is applied to the first and second electrodes therebetween. A DC voltage is applied to the third electrode and the outside one of the first and second electrodes therebetween.

Medicine applying tool

Drug administration and humor sampling unit and an apparatus therefor

There is provided a method of measuring three-dimensional distribution of ultrasonic waves which allows simple real time measurement, wherein a multiplicity of bubble-shaped elements, which are trace amounts of gas coated with an extremely thin coating, are dispersed in a liquid; an ultrasonic oscillation element is placed in the liquid to radiate ultrasonic waves; the bubble-shaped elements are collapsed by the radiation of the ultrasonic waves; and changes in the optical characteristics of the liquid caused by the collapse of the bubble-shaped elements are visually measured.

Method of measuring distribution and intensity of ultrasonic waves

A method and an apparatus for an effective chemical treatment of a blood disease apply a drug of a wider range with a smaller dose or lower concentration to the blood outside the patient's body. Blood which is collected from a patient is fed through a tube (2a) into a chamber (4) by a pump (3). A drug is injected into the chamber (4) from a container (5), while ultrasonic waves are applied to the blood contained in the chamber (4) from an actuator (7). The blood treated with the drug and by the ultrasonic waves, is returned into the body of the patient through a tube (2c), while the same is monitored by sensors (10) and (11).

Blood processing for treating blood disease

A booster comprising a plenty of microbubbles of a gas in a liquid, e.g. about 4.times.10.sup.7 cells/ml of microbubbles of a gas having a diameter of 0.1 to 100 .mu.m in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.

Booster for therapy of diseases with ultrasound and pharmaceutical

A medicinal injection instrument for injecting a medicinal medium into a living body includes a tubular arrangement for conducting a medicinal medium to an injection site, the tubular arrangement having a distal end. An ultrasonic oscillator device has an ultrasonic oscillator element juxtaposed to the distal end such that when the instrument is inserted into a living body with the distal end disposed juxtaposed to the injection site, the ultrasonic oscillator element is also disposed juxtaposed to the injection site to thereby enhance diffusion and penetration of the medicinal medium into the body tissue.

Injection instrument with ultrasonic oscillating element

Disclosed is an endermic application kit for external medicines, which comprises a drug-containing layer as provided near an ultrasonic oscillator. The kit includes a cylindrical fixed-type or portable-type and a flat regular-type or adhesive-type, and the adhesive-type may be flexible and elastic. The drug absorption is ensured by the action of the ultrasonic waves from the oscillator and the drug release can be controlled by varying the ultrasonic wave output from the oscillator.

Endermic application kits for external medicines

An endermic application kit for external medicines comprises a container for retaining liquid containing drug, a device for supplying the liquid containing drug into the container, a drug permeable layer attached to the container to cover a bottom opening of the container, and an ultrasonic oscillator situated inside the container. When the ultrasonic oscillator and supplying device are actuated, the liquid containing drug is continuously supplied to the container, and the drug contained in the liquid is applied to a skin of a patient through the drug permeable layer by means of the ultrasonic oscillator.

Growing community of inventors

Fukuoka, Japan

Shunro Tachibana