Agios Pharmaceuticals, Inc.

Ardea Biosciences, Inc

Pharmacyclics, Inc.

Servier Pharmaceuticals LLC

Les Laboratoires Servier

Shunqi Yan

Francesco Gerald Salituro

Jeffrey O Saunders

Jeremy Mark Travins

Janeta Popovici-Muller

Fang Liu

Tao Guo

Giovanni Cianchetta

Byron Delabarre

Jean-Michel Andre Vernier

Wei Yu Chen

David J Loury

Zhi Hong

Rene Marc Lemieux

Leah Lynn Frye

Longcheng Wang

Jeremy Robert Greenwood

Xuefei Tan

Zhixiong Ye

Mee Shelley

Zhaozhong Jon Jia

Ding Zhou

Zhenwei Cai

Sheldon Cao

Yung-Hyo Koh

Suetying Chow

Marion Hitchcock

Luca Francesco Raveglia

Hong Woo Kim

Gordana Babic Atallah

Maria Pia Catalani

Riccardo Zanaletti

Wei Chen

Jeremey M Travins

Li Zhang

Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

Therapeutic compounds and compositions

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

Therapeutically active compounds and their methods of use

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

Glutaminase inhibitors and method of use

Provided are aryl sulfonamide diarylurea derivative compounds that are inhibitors of mutant isocitrate dehydrogenase 1/2 (IDH 1/2), useful for treating cancer. Also provided are methods of treating cancer comprising administering to a subject in need thereof a compound described herein. Cancers that are treatable by the compounds of the invention are glioblastoma, myelodysplastic syndrome, myeloproliferative neoplasm, acute myelogenous leukemia, sarcoma, melanoma, non-small cell lung cancer, chondrosarcoma, and non-Hodgkin's lymphoma (NHL).

Provided are piperazine compounds of Formula I useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described here. 

Therapeutically active compositions and their methods of use

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Inhibitors of bruton's tyrosine kinase

Provided are compounds of formula (I), wherein X, Y, Z, W, V, R, Rand m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.

Phenyl and pyridinyl substituted piperidines and piperazines as inhibitors of IDH1 mutants and their use in treating cancer

Growing community of inventors

Irvine, CA, United States of America

Shunqi Yan