Ajinomoto Co., Ltd.

Ajinomoto., Inc.

Shunji Takehana

Takashi Kayahara

Tadakiyo Nakagawa

Kazuyuki Sagi

Kaoru Yoshida

Masaru Takayanagi

Masataka Shoji

Yumiko Fukuda

Mitsuo Takahashi

Akira Takahara

Kuniya Sakurai

Kazumi Tashiro

Masayuki Sugiki

Munetaka Tokumasu

Shingo Makino

Kohichi Fujita

Kayo Otani

Yuki Kajigaya

Yuki Saitou

Masahiro Yamanashi

Compounds represented by formula (1) and pharmaceutically acceptable salt thereofs: wherein each symbol is as defined in the specification, are useful as inhibitors of an activated blood coagulation factor X. Compositions which contain, as an active ingredient, an FXa selective low-molecular weight FXa inhibitor having a short serum half-life are particularly useful as anticoagulants for an extracorporeal blood circuit.

Benzamidine compound

Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants 

Benzamidine derivatives

Aminoisoquinoline derivatives of the following formulae or analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an excellent effect of inhibiting activated blood-coagulation factor X, and they are useful as anticoagulants or agents for preventing or treating thrombi or emboli.

Aminoisoquinoline derivatives

The present invention provides benzodiazepine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of inhibiting activated blood-coagulation factor X. These compounds are usable as agents for treating various diseases concerned with the activated blood-coagulation factor X.

Benzodiazepine derivatives

Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.

Benzamidine derivative

An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII.

Amidinophenylpyruvic acid derivatives

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Kawasaki, Japan

Shunji Takehana