Shin Nippon Biomedical Laboratories, Ltd.

Translational Research, Ltd.

The Chemo-sero-therapeutic Research Institute

Km Biologics Co., Ltd.

Satsuma Pharmaceuticals, Inc.

Shunji Haruta

Ryoichi Nagata

Toshikazu Oki

Takashi Hanafusa

Tatsuo Tsutsui

John Kollins

Genji Satoyoshi

Hideaki Mishima

Yo Sonoda

Salvador Rico

Nikhilesh N Singh

An object of the present invention is to provide a powder formulation for intranasal administration, which efficiently exhibits a medicinal effect, and the like. The object can be achieved by a powder formulation for intranasal administration comprising composite particles in which an active ingredient and a water-insoluble polysaccharide are cohered to each other.

Powder formulation for intranasal administration, and manufacturing method thereof

An object of the present invention is to provide a powder preparation and the like suitable for selective administration to an olfactory region and the like. The object is achieved by a powder preparation for selectively administering an active ingredient to an olfactory region in a nasal cavity, the powder preparation comprising the active ingredient and having a bulk density of 0.1 to 0.5 g/cmand a Hausner ratio of 1.6 to 2.4.

Powder preparation, cartridge, and device

A device according to one aspect of the present invention is an intranasal powdered medicine dispensing device () for dispensing a predetermined dose of a powdered medicine into a nasal cavity. The device includes a nozzle member () that includes a filling space () for a powdered medicine (M) and an ejection opening () for the powdered medicine (M), a closing member that closes the ejection opening (), a sealing member () that seals an opening () of the filling space (), an injection pump member () that sends out air, as the injection pump member contracts, to eject the powdered medicine from the ejection opening (), a puncturing member () that moves, as the injection pump member () contracts, and forms a hole by puncturing in the sealing member () while moving, and a guide member () that restricts the puncturing member () from moving in a direction perpendicular to the direction of the movement thereof.

Medicine dispensing device and method for manufacturing same

The present disclosure provides devices for delivery of powder formulations and methods of manufacture and use of such devices.

Intranasal delivery devices

Disclosed herein are pharmaceutical powder compositions, methods of making such compositions, and uses thereof.

Pharmaceutical compositions

A nozzled cartridge () for storing medicine, according to an aspect of the present application, includes a medicine container () that is to be filled with a predetermined quantity of a powdered medicine, a nozzle portion () that is formed on the medicine container () and that ejects the powdered medicine, a closing member () that closes an opening () in the nozzle portion (), and a valve member () that functions as a plug to close another opening () in the medicine container (), and that is opened when administering medicine. The nozzled cartridge () is detachably mountable to a sprayer () when administering medicine.

Medicine storage cartridge with nozzle, sprayer therefor, and powdered medicine dispensing device for nasal cavity

Provided herein are vaccine compositions for example in a dry powder form for intranasal delivery, and their preparation methods. Also provided are methods of using vaccine compositions, for example in stimulating mucosal or systemic immune responses by delivering the vaccine compositions intranasally.

Vaccine compositions

Provided herein are methods for generating dry vaccine powder formulations. Dry vaccine powder formulations can be used for intranasal delivery. Also provided are methods for stimulating local mucosal and systemic immunity by intranasal vaccine delivery.

Methods and compositions for intranasal delivery

[Subject] A test substance application system for animal experiment capable of administering a required amount of a test substance uniformly and reliably from a nose or a mouth into a nasal cavity or into a lung of an experimental animal is provided. [Means for Solution] The system includes a respiration monitoring devicethat monitors a respiration state of an experimental animal detected by a respiration pick-up deviceto thereby measure a timing upon switching from an expiratory phase to an inhalatory phase and outputs a trigger signal T at that timing, and an application devicethat sprays a predetermined amount of a test substance into a nasal cavity or an oral cavity of the experimental animal when the trigger signal T is outputted from the device

Test substance administration system for animal experiment

Disclosed is a preparation for transnasal application, which has improved fluidability. Specifically disclosed is a preparation for transnasal application, which comprises at least a complex comprising a fluidability-improving component comprising a first crystalline cellulose (A) having specified powder properties, tricalcium phosphate (B) having specified powder properties, and a second crystalline cellulose (C) having specified powder properties or a starch (D) having specified powder properties, and physiologically active substance.

Preparation for transnasal application

Compositions for nasal administration, which comprise a pharmaceutical, a physiologically active peptide, or a peptide-related compound, and as the carrier thereof, crystalline cellulose with a specific particle diameter and/or partially pregelatinized starch are provided. Such compositions improve the in vivo absorption efficiency of pharmaceuticals.

Compositions for nasal administration of pharmaceuticals

Methods are provided for the engineering of inhalable dry powder pharmaceutical formulations with desired pharmacokinetic profiles and parameters. Compositions with improved pharmacokinetics are disclosed.

Growing community of inventors

Kagoshima, Japan

Shunji Haruta