Yamanouchi Pharmaceutical Company Ltd.

Origin Company, Limited

Shunichi Watanabe

Toshio Sasaki

Takashi Osono

Yoshihiko Oka

Hiroshi Gushima

Takeshi Saito

Hiroshi Yamaguchi

Keisuke Murakami

Isao Takahashi

Noriki Ito

Hiroshi Ogawara

Hideo Eiki

Kiyoshi Susaki

Toshiaki Miyoshi

Shuichi Takamura

Taro Isobe

A small and compact rotation transmitter includes a torque limiter and an angular position holding apparatus. An outer race member is installed in a housing, and a coil spring is mounted on the outer peripheral surface thereof. Inside the outer race member, an internal space is formed, and an inner race member is installed concentrically with the outer race member. In the annular space between the outer and inner race members, a thin-plate elastic piece is pressed against the outer and inner race members, and either the outer or inner race member is connected to an input-side device while the other is connected to an output-side device. Even without rotation torque, the position of the output-side device is held by the coil spring. When the rotation torque from the input-side device becomes excessive, slippage occurs on the thin-plate elastic piece, whereby the outer and inner race members are disconnected.

Angular position holding apparatus with overload prevention system

Novel isoflavone derivatives are provided which have the formula ##STR1## and which exhibit cancerocidal and immunosuppressive activity. The invention also provides pharmaceutical compositions containing the derivatives, methods of use and processes for their preparation.

Isoflavone derivatives, salts thereof, and oncostatic and

Isoflavone derivatives, and salts thereof, and cancerocidal and

The 7-methoxy-3-heterocyclic thiomethyl cephalosporin derivative possessing excellent antimicrobial activity represented by the general formula ##STR1## wherein R.sup.1 represents ##STR2## group or HOOC-- group, R.sup.2 represents a nitrogen-containing heterocyclic group, and M represents a hydrogen atom or a cation residue forming a salt.

7-methoxy cephalosporin derivative

7.alpha.-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7.alpha.-methoxycephalosporin derivatives.

Process for the production of 7.alpha.-methoxycephalosporin derivatives

7.alpha.-Methoxycephalosporin derivatives

7-Methoxy cephalosporins and process of producing them

A new antibiotic substance, designated Y-G19ZD3, is produced by the fermentation of a newly discovered microorganism Streptomyces organonensis Y-G19Z or a mutant thereof. The antibiotic substance Y-G19ZD3 is effective against gram negative bacteria and is useful also as an intermediate for the production of other antibiotics.

Antibiotic Y-G19Z D3 and the production thereof

Growing community of inventors

Saitama, Japan

Shunichi Watanabe