National Institute of Advanced Industrial Science and Technology

Kyowa Hakko Kogyo Co., Ltd.

Kyoto Pharmaceutical University

Shungo Adachi

Hiroyuki Kimura

Tohru Natsume

Tetsu Akiyama

Tomoya Inoue

Katsuo Mogi

A method for producing a liquid reaction mixture containing a radioisotope, in particular, a radioactive composition, minimizes device contamination with radioactive substances and increase speed and accuracy with which droplets are mixed. The method for producing a radioactive composition includes placing at least one first droplet Lcontaining a radionuclide and at least one second droplet Lcontaining a labeling substance on at least two respective dimplesamong dimpleson a front surfaceof an insulating layerof a liquid manipulation device, and obtaining a liquid mixture M by using a change in electrostatic force caused by changing voltage applied to the electrodesto thereby cause a relative movement between the at least one first droplet Land the at least one second droplet Lso that the at least one first droplet Land the at least one second droplet Lare mixed together at any one dimple among the dimples

Method for producing radioactive composition

The present invention provides a novel &#x3b2;-catenin nuclear localizing protein and DNA encoding the protein. Furthermore, the use of the &#x3b2;-catenin nuclear localizing protein and the DNA encoding the protein provides a diagnostic agent and therapeutic agent for diseases such as cancer which is related to nuclear localization of &#x3b2;-catenin.

&#x3b2;-catenin nuclear localized protein

Growing community of inventors

Tokyo, Japan

Shungo Adachi