Kyowa Hakko Bio Co., Ltd.

Kyowa Hakko Kogyo Co., Ltd.

Shun Kayahashi

Yasushi Sakai

Toshikazu Kamiya

Hideo Kawabe

Shin-ichi Hashimoto

Masao Kimura

Akio Shirai

Ryusuke Nakagiri

Erika Hashizume

The invention provides a method of improving the preservation stability of glutathione in a solid composition containing glutathione and arginine. In particular, glutathione and arginine are made to be coexistent with an organic acid such as citric acid, tartaric acid, ascorbic acid, malic acid, malonic acid, succinic acid, fumaric acid, maleic acid and the like. The amount of the organic acid to coexistent with glutathione and arginine is generally 0.1-2 parts by weight relative to 1 part by weight of arginine.

Method for improving storage stability of glutathione

The invention provides a composition containing a fruit body ofmurill or an extract of the fruit body, and an amino acid constituting the ornithine cycle or a salt thereof, wherein the pharmacological activities of the fruit body ofmurill or the extract of the fruit body and the amino acid constituting the omithine cycle or the salt thereof are increased synergistically. Such a composition can contain a fruit body ofmurill or an extract of the fruit body, and an amino acid constituting the ornithine cycle or a salt thereof in 10-100 parts by weight per 1 part by weight of the fruit body or the extract.

[object Object]

A composition for oral administration is provided, which includes at least one dipeptide represented by the formula: (wherein X represents alanyl, and Y represents valine, leucine or isoleucine), with an object of providing a composition for oral administration which is excellent in nutrition, pharmacological effect and gustation, or providing a composition for oral administration which is excellent in processing characteristics such as solubility and tableting property.

Dipeptide-comprising composition for oral administration

A liver function protecting or improving agent which comprises a compound represented by the formula (I) {in the formula (I), R, R, R, R, R, R, R, Rand Rmay be the same or different, and represent hydrogen, halogen, hydroxy, alkoxy or alkyl; and Rrepresents the formula (II) [in the formula (II), Rand Rmay be the same or different, and represent hydrogen or halogen, or Rand Rtogether represent a binding] or the formula (III) [in the formula (III), Rrepresents hydrogen, halogen, hydroxy, alkoxy, cyano or alkyl, Rand Rmay be the same or different, and represent hydrogen or halogen, or Rand Rtogether represent a binding]} or a glycoside thereof or a pharmaceutically acceptable salt thereof.

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Tsukuba, Japan

Shun Kayahashi