Kyowa Hakko Kogyo Co., Ltd.

Other

Shun-ichi Ikeda

Yutaka Kanda

Tsutomu Akama

Yutaka Saitoh

Tatsuya Tamaoki

Hiroyuki Yamaguchi

Chikara Murakata

Tadashi Ashizawa

Tamio Mizukami

Kenichi Mochida

Hitoshi Arai

Isami Takahashi

Hiroyuki Nagata

Atsuhiro Hasegawa

Harumi Ue

Takeshi Takahashi

Hiroyuki Ishida

Yoshinori Yamashita

Masato Satomura

Hiroshi Kawamoto

Tadashi Inaba

Masanobu Takashima

Masaji Kasai

Hiroshi Takeuchi

Akira Asai

Yoshihisa Tsukada

Hiroshi Kitaguchi

Hiromitsu Saito

Katsushige Gomi

Yoshiyuki Yonetani

Naoki Asanuma

Mitsunobu Hara

Kimihisa Ueno

Tsutomu Agatsuma

Shinji Nara

Kentaro Tamaki

Takayuki Nakashima

Takayoshi Yamauchi

Yasushi Shida

Kaneaki Hattori

Uichiro Kimura

Junji Kanazawa

Kenji Nakao

Yuko Kanda

Yoko Takata

Masami Hamano

Yuko Uosaki

UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I):wherein Rrepresents hydrogen, lower alkyl, etc.; Rrepresents hydrogen, or is combined with Rto represent a bond, etc., or is combined with Rto represent &#x2014;O(C&#x2550;O)&#x2014;, etc.; Rrepresents hydrogen, etc., or is combined with Rto represent a bond, etc.; Rrepresents hydrogen, etc., or is combined with Rto represent &#x2014;(C&#x2550;O)O&#x2014;, etc.; Rrepresents hydrogen or is combined with Rto represent a bond; Rrepresents hydrogen, etc., or is combined with Rto represent a bond; Rrepresents hydrogen or is combined with Rto represent &#x2550;O; Rrepresents hydroxy or is combined with Rto represent &#x2550;O;represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.

UCS1025 derivatives

LK6-A derivatives

Pyrrolo &lsqb;4,3,2-de&rsqb; quinoline derivatives

Bisaryl compound and medicament for cancer treatment comprising the same

Agents for inducing apoptosis comprising a tetrocarcin derivative represented by the following formula (I) or a salt thereof as an active ingredient ( represents a single bond or a double bond; j and k represent 0 or 1; R to R , R to R and R represent a hydrogen atom, a lower alkyl group and the like; R , R , R , R and R to R represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like; R and R represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a group represented by the following formula (B) (R represents a formyl group and the like, R to R represent a hydrogen atom, a hydroxyl group, a lower alkyl group and the like); R represents a hydroxyl group, a lower alkoxyl group, a lower alkanoyloxy group and the like). The agents are useful as medicaments for preventive and/or therapeutic treatment of diseases resulting from increased expression of Bcl-2 family proteins, for example, cancers, AIDS and the like.

Agent for inducing apoptosis

DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents CO(CR.sup.4A R.sup.4B).sub.n1 (O(CH.sub.2).sub.p1).sub.n2 OR.sup.5 {wherein n1 represents an integer of 1 or 2; R.sup.4A and R.sup.4B are the same or different, and each represents hydrogen or lower alkyl; p1 and n2 each represents an integer of 1 to 10; and R.sup.5 represents hydrogen, lower alkyl, or the like), or ##STR2##

DC107 derivatives

DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4, or the like; R.sup.2 represents hydrogen or COR.sup.6 ; R.sup.3 represents --CH.sub.2 OCOR.sup.7, phthalimidomethyl, or the like; and W represents oxygen or NR.sup.8 (wherein R.sup.8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino).

5-Aminoflavone derivatives represented by the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and represent hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, halogen-substituted or unsubstituted lower alkanoyl or lower alkoxycarbonyl, X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2 are the same or different and represent hydrogen, halogen or lower alkyl, at least one of X.sup.1 and X.sup.2 represents halogen or lower alkyl, X.sup.3 represents hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, halogen, hydroxy, substituted or unsubstituted lower alkoxy, NR.sup.5 R.sup.6 (wherein R.sup.5 and R.sup.6 are the same or different and represent hydrogen, or substituted or unsubstituted lower alkyl, or R.sup.5 and R.sup.6 are taken together to form a heterocyclic group containing the nitrogen atom in the ring), lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, lower alkoxycarbonyl, lower alkanoyl, adizo, cyano, substituted or unsubstituted carbamoyl or lower alkylthiothiocarbonyl: or pharmaceutically acceptable salts thereof.

5-aminoflavone derivatives

Compounds having anti-inflammatory and analgesic activity of the formula ##STR1## are produced from compounds having the formula ##STR2## by rearrangement in the presence of a base or an amide and (1) X S O X.sup.1 or X S O.sub.2 X.sup.1 where X and X.sup.1 are halogen or trifluoromethyl or (2) sulfur dioxide and halogen.

Process for producing an .alpha.-aromatic group substituted alkanoic

Growing community of inventors

Sakai, Japan

Shun-ichi Ikeda