Chugai Seiyaku Kabushiki Kaisha

Shun-ichi Hata

Koji Mizuno

Isao Matsunaga

Yasuho Nishii

Minoru Shindo

Noboru Kubodera

Hiroyuki Nabata

Hiroyuki Nagano

Kazushige Sakai

Mitiro Takagi

Yasuhiro Ohba

Tamotsu Yamazaki

Kiyoshige Wakabayashi

Yasumi Uchida

Motoharu Shiba

Shin-ichi Kaiho

Etsuko Mitsuishi

Yasushi Murakami

Takashi Matsuno

Teizo Shinozaki

Masuo Koizumi

Yoshiyuki Ohsugi

Eiichi Hoshino

Shigeru Takanashi

Masamitsu Honda

Morio Kakimoto

Masayoshi Ono

Mitsuru Tanemura

Mitsura Tanemura

Akio Yoshida

Toshiaki Nakano

Phenylpiperazine derivatives of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a straight- or branched-chain saturated or unsaturated alkyl group having 1 to 8 carbon atoms which may be substituted at any position by a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group or an oxo group; and R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group, and a process for producing the same are disclosed. The derivatives of the formula have alpha blocking and serotonin antagonizing activities and are useful as a drug.

Phenyliperazine derivatives

Compounds of the formula ##STR1## (wherein R.sub.1 is a lower alkyl group, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a trifluoromethyl group or a lower alkoxycarbonyl group; two adjacent groups of R.sub.2, R.sub.3 and R.sub.4 may combine to form a methylenedioxy group; n is an integer of 2 to 6) or salts thereof, are disclosed. These compounds are useful as agents for treating circulatory diseases because they have hypotensive action and are capable of increasing the cerebral blood flow, decreasing the heart rate and suppressing ventricular arrhythmia due to myocardial ischemia.

Method for treating circulatory diseases by using (2-lower

A treating agent whose effective ingredient is an anthranyl derivative of the formula: ##STR1## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkoxy group, preferably C.sub.1 -C.sub.3 alkoxy group, a lower alkyl group, preferably C.sub.1 -C.sub.3 alkyl group, a nitro group or a halogen atom) is disclosed.

Pharmaceutical composition for treating transplanted tumor cells

An anti-peptic ulcer agent which contains as an active ingredient aminobenzoic acid compounds of the formula ##STR1## (wherein R.sub.1, R.sub.2, and R.sub.3 which may be the same or different represent a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group but they do not represent a hydrogen atom at the same time) or pharmaceutically acceptable salts thereof and a method of preventing or treating a human in need of said prevention or treatment an effective amount of said active ingredient are disclosed.

Anti-peptic ulcer agent

An agent for treating diseases in circulatory organs which comprises a piperazine compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and A are as defined hereunder, or a salt thereof and a pharmaceutically acceptable carrier.

Compositions and methods for treating diseases in circulatory organs

An aminobenzoic acid derivative represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined hereinbelow, which has excellent activity for improving liver function and for potentiating and normalizing immunity; a process for preparing the same; and a pharmaceutical composition containing the same are disclosed.

Novel aminobenzoic acid derivatives, process for preparing the same and

A pharmaceutical composition for reducing the alcohol content or slowing the rate of increase thereof in the blood and inhibiting the accumulation of neutral lipid in the liver containing a uridine diphosphate as an effective ingredient and a method of the use thereof are disclosed.

Method for treating alcoholism

A pharmaceutical composition for treating alcoholism containing a uridine diphosphate glucuronic acid as an effective ingredient and a method of the use thereof are disclosed.

Method of treating alcoholism

Phthalazine derivatives represented by the formula ##STR1## and salts thereof which are useful for a luminescence immuno assay, or a process for preparing the same are disclosed.

Phthalazine derivatives and salts thereof

A novel nitrogen-containing carbohydrate can be obtained from a proliferating tissue. The carbohydrate has an activity against transplanted Krebs-2 and Sarcoma-180 tumors in mice and also may be used as a diagnostic ingredient for the detection of such tumors.

Nitrogen-containing carbohydrate

Growing community of inventors

Yokohama, Japan

Shun-ichi Hata