Takeda Pharmaceutical Company Limited

Shumpei Murata

Masato Yoshikawa

Masaki Seto

Tsuneo Oda

Yusuke Sasaki

Akito Shibuya

Zenyu Shiokawa

Michiyo Mochizuki

Morihisa Saitoh

Yusuke Tominari

Paul D Greenspan

Yasufumi Wada

Tomohiro Seki

Brian Scott Freeze

Taisuke Tawaraishi

Kosuke Hidaka

Yoshihisa Nakada

Yayoi Nakayama

Yasuo Nakagawa

Taisuke Kato

Tadashi Umemoto

Atsutoshi Okabe

Masanori Okaniwa

Naoki Miyamoto

Kenichi Miyata

Yayoi Yoshitomi

Shinichi Masada

Yoji Hayase

The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Methods of making a cyclic dinucleotide

Antibody-drug conjugates comprising a cyclic dinucleotide

Provided is an oligonucleic acid analog which contains, as at least one structural unit thereof, a modified nucleic acid monomer compound which is a ring-open nucleoside having a cleaved carbon-carbon bond between the 2' and 3&#x2032; positions and a substituent hydroxymethyl group at the 4&#x2032; position. When used as siRNA, the oligonucleic acid analog exhibits superior biological stability and target gene expression inhibiting activity. The oligonucleic acid analog can be used in antisense methods, ribozyme methods, and decoy methods, etc., can be used as a nucleic acid aptamer, and can also be used as a nucleic acid probe or molecular beacon, etc., or in genetic diagnostics, etc.

Modified nucleic acid

There is a demand for a convenient production method of an NC type purine nucleoside. The present invention relates to a method of producing a purine nucleoside represented the formula (I') or a salt thereof, which comprising reacting a pyrimidine nucleoside represented by the formula (I) or a salt thereof with a purine nucleobase represented by the formula B&#x2032;H in the presence of a Lewis acid.

Process for producing nucleoside

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Fujisawa, Japan

Shumpei Murata