Chugai Seiyaku Kabushiki Kaisha

The University of Tokyo

Other

Perseus Proteomics Inc.

Haplopharma Inc.

Aburatani, Hiroyuki

Shumpei Ishikawa

Hiroyuki Aburatani

Yukio Ito

Hirokazu Taniguchi

Toshihiko Ohtomo

Hirotaka Ito

Shogo Yamamoto

Yoshitaka Hippo

Yong Xin Chen

Shin-ichi Fukumoto

Takahiro Shimamura

Ying Qiu Guo

Naoko Kamimura

Kenji Yoshida

Shigeto Kawai

Daisuke Komura

Takashi Nishizawa

Akihiro Kawabe

Miwako Kakiuchi

Naoka Kamimura

Shin-Ichi Fukumoto

Toshihiko c/o Chugai Seiyaku K K Ohtomo

Yukio c/o Perseus Proteomics Inc Ito

Hirotaka c/o Chugai Seiyaku K K Ito

An image extraction device, an image extraction system, an image extraction method, and an image extraction program are capable of extracting an appropriate reference image from a database by using a pathological image as a query. The image extraction device includes: an acquisition unit which acquires a pathological image; a first calculation unit which calculates a local feature amount of the pathological image; a second calculation unit which calculates a non-local feature amount based on a correlation with the local feature amount; a third calculation unit which calculates a degree of similarity between the non-local feature amount and a feature amount of each of a plurality of reference images stored in a database; and an extraction unit which extracts one or more reference images based on the degree of similarity.

Image extraction device, image extraction system, image extraction method, and image extraction program

It is intended to disclose an antibody which binds to DLL3 protein. Preferably, the antibody of the present invention recognizes a region from amino acids 216 to 492 in human DLL3 having the amino acid sequence as set forth in SEQ ID NO: 1. The present invention also provides a pharmaceutical composition, for example, an anticancer agent, comprising the antibody of the present invention as an active ingredient. The present invention further discloses a method for diagnosing cancer using the antibody of the present invention and a diagnostic drug for cancer comprising the antibody of the present invention.

Anti-DLL3 antibody

Disclosed are a novel method of detecting cancer, a method of screening inhibitors and anticancer agents that target cancer-related molecules, RHOA polypeptide having mutation and a polynucleotide encoding the polypeptide as a therapeutic agent for cancer, and a method of detecting cancer using the polypeptide or polynucleotide. Also disclosed are a vector and a host cell comprising the polynucleotide, a method of screening therapeutic agents for cancer comprising the polypeptide and/or the polynucleotide, and a therapeutic agent for cancer comprising siRNA having a silencing effect on RHOA mutant.

Use of RHOA in cancer diagnosis and inhibitor screening

Disclosed is a monoclonal antibody binding to an ITM2A protein. This antibody is useful in the diagnosis, prevention, and treatment of cancer such as Ewing's sarcoma, T cell leukemia, T cell lymphoma, acute myeloid leukemia, B cell tumor, and multiple myeloma. The present invention also provides a pharmaceutical composition, a cell growth inhibitor, and an anticancer agent containing the antibody as an active ingredient, and a method for treating cancer, a method for predicting the efficacy of cancer treatment, and a method for determining the presence of cancer in a test subject using the antibody.

Diagnosis and treatment of cancer using anti-ITM2A antibody

Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

Gene overexpressed in cancer

This invention relates to a method for searching for a genetic polymorphism for identifying a gene whose expression level is different between alleles and to a method for searching for a phenotype-associated genetic polymorphism. More particularly, the invention relates to a method for effectively identifying a gene whose expression level is different between alleles by utilizing a genetic polymorphism present in intranuclear RNA.

Method for identifying gene with varying expression levels

Growing community of inventors

Tokyo, Japan

Shumpei Ishikawa