Jiangnan University

Shumao Cui

Gang Wang

Hao Zhang

Jianxin Zhao

Qixiao Zhai

Wenwei Lu

Bo Yang

Fengwei Tian

Meiyi Zhang

Leilei Yu

Bingyong Mao

Zhexin Fan

Xi Liang

Qingmin Kong

The present disclosure discloses multifunctional lactobacilli capable of relieving a toxic effect of perfluorooctanoic acid (PFOA) and use thereof, and belongs to the technical field of microorganisms.CCFM1051,CCFM1052 andCCFM1053 of the present disclosure have high adsorption effect on PFOA, can significantly relieve liver oxidative stress damage and serum biochemical indicators caused by PFOA, spleen atrophy caused by PFOA exposure, imbalance of intestinal microorganisms caused by PFOA exposure and metabolic disorder of intestinal flora caused by PFOA exposure, significantly increase the content of acetic acid and propionic acid in the intestinal tract, increase the fecal water content and decrease first black stool defecation time of mice with constipation, improve proliferation and MafA gene expression of INS-1 cells under high glucose, have the potential to relieve PFOA-related diabetes, reduce occurrence of liver diseases, metabolic diseases and potential carcinogenicity, and have broad use prospects.

Multifunctionalcapable of relieving PFOA toxic effects and application thereof

Described is astrain for relieving rheumatoid arthritis and application thereof, belonging to the technical field of microorganisms. Described is astrain CCFM1078 possessing the effect of relieving rheumatoid arthritis, and shown to: promote secretion of anti-inflammatory factor IL-10 from RAW264.7 cells; reduce joint thickness, clinical score, and incidence of rats with rheumatoid arthritis; decrease levels of the pro-inflammatory cytokines TNFα and IL-1β in the serum of rats with rheumatoid arthritis; regulate the content of short-chain fatty acids in the feces of rats with rheumatoid arthritis; decrease the proportion of Th17 cells in the mesenteric lymph nodes of rats with rheumatoid arthritis; and reduce secretion of pro-inflammatory factor IL-6 from synovial cells.

Bifidobacterium breve capable of relieving rheumatoid arthritis and application thereof

The disclosure discloses a strain ofand application thereof in inhibiting, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain ofCCFM1119. TheCCFM1119 can prevent and/or treatinfection, specifically embodied in that: (1) theCCFM1119 can significantly relieve the gastrointestinal symptoms of patients withinfection; (2) theCCFM1119 can significantly reduce the amount of colonization ofin patients withinfection; and (3) theCCFM1119 can significantly increase the clearance rate ofin patients withinfection. Therefore,CCFM1119 has great application prospects in the preparation of products (such as food or medicine) for preventing and/or treatinginfection.

Strain ofand application thereof in inhibiting

Growing community of inventors

Wuxi, China

Shumao Cui