University of Pennsylvania

Shulamith Radin

Paul Ducheyne

Erick Manuel Santos

Sylvie Falaize

Portonovo S Ayyaswamy

Xerogel films on substrates are provided containing pharmaceutically active compounds. Articles incorporating such films are robust, release active compounds at predictable rates and may provide such release for relatively long periods of time. Orthopedic and trauma uses are indicated along with generalized use in contact with body fluids or as biological implants. Methods for fabrication of such films and devices are provided.

Xerogel films for the controlled release of pharmaceutically active molecules

Conditioning of the surface of silica-based glass or ceramic by differential immersion in a serum protein-containing solution, and the resultant microporous Ca-P surface layer having serum-protein like organic molecules, as defined herein intermingled throughout, is described.

Conditioning of bioactive glass surfaces in protein containing solutions

Hollow particles having a shell substantially composed of calcium-phosphate, methods for preparing the same, and methods of use are disclosed. The particles are obtained by differential immersion of silica-based, calcium and phosphate containing glass particles.

Hollow bone mineral-like calcium phosphate particles

Conditioning of the surface of silica-based glass or ceramic by differential immersion in a serum protein-containing solution, and the resultant microporous Ca&mdash;P surface layer having serum-protein like organic molecules, as defined herein intermingled throughout, is described.

Carriers comprising silica-based glass providing for the controlled release of biologically active molecules, their methods of preparation, and methods of use are disclosed. The carriers are prepared using a sol-gel-derived process. Biologically active molecules are incorporated within the matrix of the glass during production.

Incorporation of biological molecules into bioactive glasses

Incorporation of biologically active molecules into bioactive glasses

Methods for increasing the biocompatibility of silica-based glass having a concentration of silicon greater than 55%, compositions resulting therefrom, and methods for expeditious formation of calcium-phosphate films on sol-gel derived, silica-based bioactive glass are disclosed.

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Voorhees, NJ, United States of America

Shulamith Radin