Kyowa Hakko Kirin Co., Limited

Shuko Okazaki

Kyoichiro Iida

Yukihito Tsukumo

Nobumasa Otsubo

Kenji Uchida

Hitoshi Arai

Masayoshi Nakoji

Takamichi Imaizumi

Fumitake Takizawa

Yuichi Matsumoto

Provided are a compound represented by general formula (I), or the pharmaceutically acceptable salt thereof, (wherein Rrepresents a hydrogen atom or the like, Rand Rmay be the same or different, and each represents a hydrogen atom, optionally substituted lower alkyl or cycloalkyl, or Rand Rare combined together with the adjacent nitrogen atom thereto to form nitrogen-containing heterocyclic group, and Z represents a bicyclic heterocyclic group in which optionally substituted two six-membered rings are fused to each other, or the like) and the like.

Pyrimidodiazepinone compound

The invention provides a pyrimidodiazepinone derivative represented by the general formula (I) [wherein n represents 1 or 2, Z represents a hydrogen atom or the like, Rand Rmay be the same or different, and each represents a hydrogen atom or the like, A represents a bond, (CH)(wherein m represents an integer of 1 to 4), optionally substituted phenylene, optionally substituted pyridinediyl, or C&#x2550;O, Rrepresents a hydrogen atom, optionally substituted lower alkyl, or the like, and Rrepresents a hydrogen atom or the like], or a pharmaceutically acceptable salt thereof or the like.

Pyrimidodiazepinone derivative

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Tokyo, Japan

Shuko Okazaki