Shionogi Company Limited

Shuji Yonezawa

Yukio Tada

Yuusuke Tamura

Yuuji Kooriyama

Tatsuhiko Ueno

Chiaki Fujikoshi

Sae Matsumoto

Shinji Suzuki

Akihiro Hori

Gaku Sakaguchi

Yuki Murakami

Terukazu Kato

Kenichi Ishibashi

Crystals of a quinazoline derivative are provided. The present invention relates to an acid addition salt of a compound represented by Formula (I): a pharmaceutical composition containing it, and the like.

Salts of quinazoline derivative or crystals thereof, and the process for producing thereof

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid &#x3b2; protein, for example, 

Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity

This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; Ris optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; Rand Rare each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R, R, Rand Rare each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.;a pharmaceutically acceptable salt or solvate thereof,which is useful for treating diseases induced by production, secretion and/or deposition of amyloid &#x3b2; protein.

Aminodihydrothiazine derivatives substituted with a cyclic group

The present invention provides a compound which has an effect of inhibiting amyloid-&#x3b2; production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-&#x3b2; proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; Ris a group such as optionally substituted lower alkyl; Ris a group such as hydrogen; and Rand Rare each independently a group such as hydrogen, provided that the following compound is excluded. 

2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity

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Osaka, Japan

Shuji Yonezawa