Niigata University

Yamaguchi University

Shibuya Corporation

Sunarrow Limited

Shuji Terai

Kenji Yoneda

Naoki Yamamoto

Hiroki Sato

Isao Sakaida

Atsushi Ogawa

Koichi Fujisawa

Ken-ichi Mizuno

Atsunori Tsuchiya

Suguru Takeuchi

Taro Takami

Yutaka Kuwabara

An induction method for a macrophage is provided, in which macrophages are cultured in the presence of exosomes produced from a mesenchymal stem cell to which interferon gamma has been added and are induced into anti-inflammatory macrophages. An anti-inflammatory macrophage-inducing agent includes exosomes produced from a mesenchymal stem cell to which interferon gamma has been added, as an active component. A pharmaceutical composition contains the inducing agent.

Induction method for macrophage, anti-inflammatory macrophage-inducing agent, and pharmaceutical composition

A method for evaluating the activity level of mesenchymal stem cells, and a method for culturing mesenchymal stem cells using the evaluation method in the field of culturing mesenchymal stem cells for regenerative medicine, and further, a method for producing a therapeutic agent for liver dysfunction and a therapeutic agent for liver dysfunction. This method for evaluating mesenchymal stem cell activity has an assay step for assaying the amount of adenylate kinase 4 (AK4) in the mesenchymal stem cells; and a determination step for determining the activity level of the mesenchymal stem cells from the assayed amount of adenylate kinase 4.

Method for evaluating mesenchymal stem cell activity, method for culturing mesenchymal stem cells, method for producing therapeutic agent for liver dysfunction, and therapeutic agent for liver dysfunction

Provided is a pseudo visceral model having a specific texture. A model of viscera, tissues, or organs comprising a foam layer containing a hydrogel.

Model of viscera, tissues, or organs

Growing community of inventors

Niigata, Japan

Shuji Terai