Sankyo Company, Limited

Nec Corporation

Fujifilm Corporation

Shuji Takahashi

Takeshi Kagasaki

Hideyuki Haruyama

Hideyuki Shiozawa

Kentaro Kodama

Akira Ishii

Takao Okazaki

Toshiaki Yanai

Seigo Iwado

Hisaki Kajino

Ryuzo Enokita

Keiji Tanaka

Kaneo Ogawa

Masaaki Takahashi

Mutsuo Nakajima

Takeshi Kinoshita

Akio Torikata

Koichi Hirai

Kiyoshi Hamano

Yuji Iwano

Kazuhiko Tanzawa

Yoshiharu Sakaida

Tsuyoshi Hosoya

Osamu Ando

Katsumi Fujimoto

Hidetsune Tamaoki

Akira Sato

Yasuyuki Takamatsu

Yoshinori Inaoka

Method for supporting the design of semiconductor integrated circuit and system using the same method

A semiconductor integrated circuit designing system comprises an input unit for receiving input of parameters regarding circuit blocks constituting an LSI, a repeater information calculation unit for obtaining information regarding repeater insertion by using applied parameters, a circuit block arrangement unit for arranging circuit blocks based on information regarding repeater insertion, a delay calculation unit for calculating a wire delay of wiring between arranged circuit blocks, a cycle time calculation unit for obtaining a cycle time of the entire LSI based on a calculated delay value, and a detailed wiring unit for conducting detailed wiring within a circuit block on an LSI whose arrangement on a circuit block basis and wiring processing have been completed.

Semiconductor integrated circuit designing system taking insertion of repeaters into consideration and designing method thereof

Compounds of formula (I): ##STR1## (wherein R represents a hydrogen atom or an acetyl group), which we have named 'the adenophostins', and, have the ability to increase intracellular calcium ion concentrations by acting on the inositol 1,4,5-trisphosphate (InsP.sub.3) receptors which exist in the endoplasmic reticulum. The adenophostins are useful as hypertensive agents. They can be prepared by cultivation of a microorganism of the genus Penicillium, e.g. Penicillium brevicompactum SANK 11991 (FERM BP-3499) or Penicillium brevicompactum SANK 12177 (FERM BP-3500).

Adenophostins

The present invention relates to a novel antibacterial compound obtainable from the genus Alteromonas and which shares structural similarity with the pseudomonic acids.

Culture of alteromonas and process of using the same to produce an

Two thiomarinol derivatives, which have antibacterial and anti-mycoplasmal properties, are obtainable from microorganisms of the genus Alteromonas and are named 'thiomarinol B' and 'thiomarinol C'. Thiomarinol B can also be prepared by the oxidation of thiomarinol.

Thiomarinol compounds

Anti-bacterial compound and pharmaceutical compositions thereof

5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol and 2-amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5, 6-triol, which have the ability to inhibit the activity of sugar hydrolases, especially .beta.-glucosidase and sucrase and can thus be used for the treatment and prophylaxis of tumorous conditions, AIDS, diabetes and obesity, can be prepared by hydrolysis of trehazolin. 2-Amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5, 6-triol can also be prepared by fermentation using newly isolated strains Micromonospora sp. SANK 62390, FERM BP-3521 and Amycolatopsis sp. SANK 60791, FERM BP-3513.

Polyhydroxycyclopentane derivatives, their preparation and their

Compounds with acaricidal, insecticidal and anthelmintic activities have the formula: ##STR1## wherein: --X--Y-- is selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHOH--, --CH.dbd.CH--, and --CH.sub.2 --C(.dbd.O)--;

Macrolide compounds, their preparation and their use

Propioxatins A and B, which have the formula: ##STR1## wherein R represents a hydrogen atom or a methyl group, can be prepared by cultivating a suitable strain of Kitasatosporia, e.g. Kitasatosporia sp. SANK 60684 (FERM-P 7581). They can be salified to give pharmaceutically acceptable salts. The compounds are active as enkephalinase B inhibitors and are thus capable of enhancing enkephalin activity in vivo.

Enkephalinase B inhibitors, their preparation, and pharmaceutical

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Tokyo, Japan

Shuji Takahashi