Chugai Seiyaku Kabushiki Kaisha

Shuji Sumida

Yoshimitsu Iida

Yasushi Sato

Takashi Terazono

A stable granulocyte colony-stimulating factor-containing formulation comprising a granulocyte colony-stimulating factor and at least one pharmaceutically acceptable surfactant in an amount of 1 part by weight or less per part by weight of the granulocyte colony-stimulating factor and having a pH of 7 or less.

Protein free formulations

A slow-release pharmaceutical agent which comprises fumaric acid and/or DL-tryptophan in addition to one or more pharmaceutically active substances, and a process for preparation of the same are disclosed. Among many organic acids and amino acids, fumaric acid and DL-tryptophan are remarkably useful for extending the duration of release of a pharmacologically active substance when fumaric acid, DL-tryptophan or both is used for formulation of a pharmaceutical agent. The pharmaceutical agent may be in any solid form of formulations such as powder, granule, tablet, troche, capsule, suppository, etc., and may be used with practically all types of drugs.

Slow-release pharmaceutical agent

A method for producing a stable preparation containing nicorandil, a saturated higher aliphatic acid or a saturated higher alcohol which is solid at ordinary temperatures, and optionally, an organic acid such as fumaric acid, oxalic acid, salicylic acid, tartaric acid or glutaric acid is disclosed. Nicorandil is useful as a curative for various types of angina pectoris. However, it is unstable in humid conditions and under the compressive pressure exerted by punching operations in tablets making and, therefore, the development of a stable nicorandil preparation has been desired.

Method for production of stable nicorandil preparation

A method for producing a stable pharmaceutical preparation containing nicorandil as an active ingredient is disclosed. The stable preparation is produced by mixing nicorandil, one or more finely comminuted sugars, and/or one or more powdery organic acids. Nicorandil which is useful as a curative for various types of angina pectoris is not stable against the compressive pressure exerted by punching operations in tabelt making or against moisture. The preparation of nicorandil manufactured by this invention is very stable and useful in clinical applications.

Growing community of inventors

Tokyo, Japan

Shuji Sumida