Toto Ltd.

Shuji Sonezaki

Koki Kanehira

Yumi Ogami

Toshiaki Banzai

Makoto Bekki

Yoshinobu Kubota

Hiromasa Tokudome

Hitoshi Ohara

Hiroshi Ishikawa

Yumi Osaki

Yoko Yamada

Masahiro Miyauchi

Yukiko Koyama

Tomomi Nakamura

There is provided an ultrasonic cancer treatment enhancer and cell killer that can significantly improve the effect of treating cancer by ultrasonic irradiation while ensuring a high level of safety. The ultrasonic cancer treatment enhancer and cell killer comprise metal semiconductor particles and can be activated upon ultrasonic irradiation to kill or destruct cancer cells.

Ultrasonic cancer treatment enhancer and cell killer

In utilizing photocurrent generated in the photoexcitation of a dye in specific detection of an analyte, highly accurate detection can be realized by discharging charged current generated in the formation of a sensor unit and, in the detection of photocurrent of a plurality of detection spots provided on a working electrode, discharging photocurrent which is derived from a detection spot subjected to the latest photocurrent measurement and becomes noise current. The present invention provides a measuring apparatus comprising a sensor unit comprising a working electrode, a counter electrode, and an electrolyte-containing substance, a single or plurality of light sources that apply light to the working electrode, an XY moving device provided when the light source is moved relatively in an XY direction relative to the working electrode, an ammeter that measures current which flows across the working electrode and the counter electrode, and a discharge device that discharges charged current and photocurrent derived from a detection spot subjected to the latest photocurrent measurement. The specific detection method using the measuring apparatus is carried out by controlling the timing of light irradiation and the timing of connection to the ammeter and the discharge device.

Measurement device used for specifically detecting substance to be examined using photocurrent, sensor unit used for same, and method for specifically detecting substance to be examined using photocurrent

A titanium dioxide composite is provided that can be stably dispersed in an aqueous solvent and easily administered into a living body, such as human, and allows elimination of the drug efficacy of a pharmaceutical compound supported thereon by light irradiation and a dispersion thereof. A composite is used in which a pharmaceutical compound is bound to titanium dioxide having photocatalytic activity through a hydrophilic polymer. The composite is stable in an aqueous solvent and easily administered into a living body, and adverse drug reactions of the pharmaceutical compound can be reduced by administering the composite into the body and irradiating the composite with a light to photoexcite the titanium dioxide to decompose the pharmaceutical compound in a region where the drug efficacy of the pharmaceutical composition is not required.

Therapeutic method of administering pharmaceutical titanium dioxide composite and light irradiation

A method, an electrode, a measuring cell, and a measuring device are disclosed which can detect and quantitatively determine an analyte having specific bonding properties, in a highly sensitive, simple and accurate manner using photocurrent. This method comprises contacting a working electrode and a counter electrode with an electrolyte medium, wherein the working electrode has an analyte immobilized thereon through a probe substance and wherein the analyte is bonded to a sensitizing dye; irradiating the working electrode with light to photoexcite the sensitizing dye; and detecting photocurrent flowing between the working electrode and the counter electrode, wherein the photocurrent is generated by transfer of electrons from the photoexcited sensitizing dye to the working electrode. The working electrode comprises an electron accepting layer comprising an electron accepting substance capable of accepting electrons released from the sensitizing dye in response to photoexcitation, wherein the probe substance is supported on a surface of the electron accepting layer. The electron accepting substance is an oxide semiconductor having an energy level lower than that of a lowest unoccupied molecular orbit (LUMO) of the sensitizing dye. The electrolyte medium comprises an electrolyte and at least one solvent selected from an aprotic solvent and a protic solvent, wherein the electrolyte comprises a salt capable of providing an oxidized sensitizing dye with electrons.

Method for specifically detecting analyte using photocurrent, and electrode, measuring cell and measuring device for use therein

The present invention relates to a method of expressing an objective protein at a high level and stably as well as for a long period even in the absence of a selection drug with a recombinant mammal cell. More particularly, the present invention relates to a method of producing an objective protein by providing a recombinant mammal cell having multiple copies of the exogenous objective protein gene expression unit integrated into a hypoxanthine-phosphoribosyl transferase enzyme (hprt) gene locus and culturing said cell.

Recombinant mammal cells, method of producing thereof, and method of producing proteins of interest

Growing community of inventors

Kitakyushu, Japan

Shuji Sonezaki