Other

Shuji Akai

Hirofumi Yamamoto

Xin Wu

Masaki Mori

The present invention provides a safe and effective DDS technique that realizes higher accumulation in lesions and reduced accumulation in normal organs including the liver, and thus can afford sufficient therapeutic effects with smaller amounts of drugs. Specifically, a composition containing carbonate apatite particles loaded with a drug, wherein the particles have an average particle size of larger than 500 nm and not more than 1000 nm, primary particles are formed in the presence of a polyethylene glycol (PEG) derivative having one or more carboxylic acids or derivatives thereof or salts thereof at the ends thereof, and the PEG derivative is taken up in the primary particles, is provided.

Growing community of inventors

Nishinomiya, Japan

Shuji Akai