Aska Pharmaceutical Co., Ltd.

Teikoku Hormone Mfg. Co., Ltd.

Other

Teikoju Hormone Mfg. Co., Ltd.

Shuichiro Sato

Takahisa Saito

Jun Sato

Koichi Hasumi

Hajime Asano

Shuji Ohta

Makoto Okada

Akira Asagarasu

Katsuyuki Keino

Hideo Kobayashi

Michitaka Sato

Satoshi Doi

Nobuyoshi Minami

Kotaro Gotanda

Norio Yamamoto

Youichi Nakano

Teruaki Matsui

Motohiro Kobayashi

Atsushi Shinbo

Arihiro Kanada

Kenji Kawade

Hiroyuki Suzuki

Kazuhiko Shirota

Jun-ya Kato

Mami Okada

Yasuhiro Matsumoto

Jun-Ya Kato

Masafumi Shiraiwa

Hiroshi Azuma

Akiko Sugimoto

Katsura Suzuki

Hidehisa Hamasaki

Haruo Yamashita

Koji Doguchi

Shuji Ota

The invention discloses quinoxaline derivatives or salts thereof having PDE9-inhibiting activity and being useful as treating agent of dysuria and the like, which are represented by the formula (I) in the formula,

Substituted pyrrolo[1,2-a]quinoxalines as PDE9 inhibitors

Substituted imidazo[1,5-A]quinoxalines as phosphodiesterase 9 inhibitors

Substituted imidazo[1,5-A] quinoxalines as a PDE9 inhibitor

This invention offers isoxazole derivatives represented by the following formula (I) 

Pyridylisoxazole derivatives

The invention discloses quinazoline derivatives or salts thereof, which possess PDE9-inhibiting activity and are useful as treating agents of dysuria and the like, the derivatives being represented by the formula (I) 

Quinazoline derivatives

The invention discloses isoxazole derivatives represented by a formula, 

Pyrimidinylisoxazole derivatives

Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein Ris &#x2014;CH(OH)&#x2014;CH(R)-(A)-Y, &#x2014;CH&#x2014;CH(R)-(A)-Y, &#x2014;CO-B-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; Ris a hydrogen atom or a lower alkyl group; Bis &#x2014;CH(R)&#x2014; or &#x2014;N(R)&#x2014;; and n is 0 or 1); Ris a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; Ris a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &#x3b1;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases 

Substituted pyrazole compounds

Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R is &mdash;CH(OH)&mdash;CH(R )&mdash;(A) &mdash;Y, &mdash;CH &mdash;CH(R )&mdash;(A) &mdash;Y, &mdash;CO&mdash;B &mdash;A&mdash;Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R is a hydrogen atom or a lower alkyl group; B is &mdash;CH(R )&mdash; or &mdash;N(R )&mdash;; and n is 0 or 1); R is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.

Aminopyrazole derivatives

4,5-Dihydro-&lsqb;1H&rsqb;-benz&lsqb;g&rsqb;indazole-3-carboxylic acid derivatives represented by the following formula, or their salts, have excellent antagonism to endothelin receptors and are useful as preventives or remedies for diseases such as hypertension, angina pectoris, myocardial infarction, brain infarction, cerebrovascular contraction, renal insufficiency, hepatic dysfunction, arteriosclerosis and post-PTCA restenosis.

4,5-dihydro-&lsqb;1H&rsqb;-benz&lsqb;g&rsqb;indazole-3-carboxylic acid derivatives

Process for the preparation of 2,6-disubstituted benzothiophene compounds

Growing community of inventors

Komae, Japan

Shuichiro Sato