Daiichi Pharmaceutical Co., Ltd.

Daiichi Seiyaku Co., Ltd.

Shuichi Yokohama

Isao Hayakawa

Shohgo Atarashi

Masazumi Imamura

Nobuyuki Higashihashi

Katsuichi Sakano

Masayuki Ohshima

Norio Suzuki

Hiroyuki Fujiwara

Atsushi Nakayama

Masashi Hasegawa

Yasuyuki Takeda

Shunzo Aibara

Tamotsu Miwa

Hiroo Matsumoto

Sumiro Isoda

Toru Hosokami

Yoshihiro Yokomizo

Aki Yokomizo

Keiichi Kawagoe

Aminophenol derivatives

An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.

Optically active pyridobenzoxazine derivatives and intermediates thereof

A compound represented by the following formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group or a cyclic alkyl group;

Pyrrolo(2,1-B)thiazole derivatives

Optically active pyridobenzoxazine derivatives and anti-microbial use

Novel tricyclic triazolopyrimidine compounds represented by formula (I) shown in the specification and physiologically acceptable salts thereof are disclosed. These compounds have an excellent anti-allergic activity and are useful for treatment and prophylaxis of allergic diseases.

Tricyclic triazolopyrimidine derivatives

Novel 4-oxoguinoline-3-carboxylic acid derivatives having the formula ##STR1## wherein X.sup.1 represents a halogen or hydrogen atom, X.sup.2 represents a halogen or hydrogen atom, X.sup.3 represents a halogen atom, and R.sup.1, R.sup.2 and R.sup.3 each represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and physiologically acceptable salts thereof, are disclosed. These compounds have excellent antibacterial activity against gram-positive and gram-negative bacteria and beneficial pharmacokinetic properties.

Quinoline-carboxylic acid derivatives

Growing community of inventors

Tokyo, Japan

Shuichi Yokohama