Sagami Chemical Research Center

Shuichi Mitamura

Katsuyuki Ogura

Genichi Tsuchihashi

Koji Kitajima

Gehichi Tsuchihashi

Kumi Kobayashi

A manufacturing method is described for the preparation of optically active 1-(6-methoxy-2-naphthyl)-2-(alkoxycarbonyl)amino-1-propanone, its derivatives and their halo analogs. The optically active 1-(6-methoxy-2-naphthyl)-2-(alkoxycarbonyl)amino-1-propanone, its derivatives and their halo analogs are useful intermediates in the preparation of 2-(6-methoxy-2-naphthyl)propionic acid, which is useful as pharmaceutical, e.g. antiinflammatory, analgesic and anti-pyretic agents.

Optically active 1-(6-methoxy-2-naphthyl)-2-(alkoxycarbonyl)

An alpha-thio-alpha-aryl-substituted alkanonitrile of the general formula ##STR1## wherein Ar represents an aromatic group, R represents a hydrogen atom or an alkyl group, R.sup.1 represents an alkyl group or an aromatic group, and Y represents an oxygen atom or a carbonyl group. The above compound can be prepared by reacting an alpha-aryl-substituted-alpha-thio-acetonitrile of the general formula ##STR2## wherein Ar, Y and R.sup.1 are as defined above, with an alkylating agent in the presence of a strong base. This compound is useful as an intermediate for producing an alpha-aryl-substituted alkane-carboxylic acid of the general formula ##STR3## wherein Ar, Y and R.sup.1 are as defined above.

Alpha-thio-alpha-aryl-substituted alkanonitrile and process for

The present invention provides .alpha.-methylthio-.alpha.-(p-phthalimidophenyl)-propionic acid and its esters of the formula: ##STR1## wherein R' represents H or C.sub.1 -C.sub.4 alkyl. The subject compounds are useful as intermediates e.g. for Indoprofen.

.alpha.-Methylthio-.alpha.-(p-phthalimidophenyl)-propionic acid

Novel .alpha.-thio-alkanoic acid derivatives and a process for their preparation. These novel compounds can be easily converted to useful medicines.

Growing community of inventors

Sagamihara, Japan

Shuichi Mitamura