Meiji Seika Kaisha, Ltd.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Shuichi Gomi

Tomio Takeuchi

Shinichi Kondo

Seiji Shibahara

Keiichi Ajito

Masaji Sezaki

Masa Hamada

Akira Shimizu

Haruo Yamamoto

Osamu Hara

Yoko Ikeda

Takeshi Hara

Daishiro Ikeda

Atsushi Tamura

Hiroo Hoshino

Akitaka Nakane

Shinji Miyadoh

Toshiaki Kudo

Takayuki Usui

Shoichi Murakami

Dai Kubota

Minako Araake

Mikio Yamamoto

Ken-ichi Kurihara

Tsuneo Ishizuka

Nobue Kikuchi

Minoru Ishikawa

Aiko Miyata

Masaru Shimura

Takashi Shomura

Kiyoaki Katano

Naomi Sumida

Koji Yanai

Mitsugu Hachisu

Toshiaki Kono

Takashi Yaguchi

Jinichiro Koga

Hidetoshi Kubota

Michiaki Iwata

Yuko Baba

Takayoshi Fukushima

Shinjiro Sumi

Shigeharu Inoye

Katsuo Aizawa

Masato Tani

Tomoko Nishimura

Kazuyuki Fujishima

Satoshi Hanamura

Hirotada Takahashi

Noriaki Aman

Yoshihiko Terayama

Kei-ichi Imamura

Eriko Tanaka

Yasumasa Ota

Naokazu Yahata

Rie Shinei

Shokichi Ouchi

The present invention relates to novel aminoglycoside antibiotics, a process for producing the same, and pharmaceutical use thereof. More specifically, the present invention relates to compounds represented by formula (I), a process for producing the same, and use of the same as antimicrobial agents. wherein R represents amino or hydroxyl.

Aminoglycoside antibiotics, process for producing the same, and pharmaceutical use thereof

A novel endoglucanase derived from, a polynucleotide encoding the endoglucanase, and a cellulase preparation containing the endoglucanase are disclosed. The endoglucanase or cellulase preparation is available for a washing use or fabric processing, such as a color clarification of a cellulose-containing fabric, a reduction of fuzz, an improvement of the touch feel and appearance of the fabric, providing a localized color change to the fabric, or a reduction of stiffness.

Endoglucanase STCE and cellulase preparation containing the same

&OHgr;-amino-&agr;-hydroxycarboxylic acid derivatives having integrin &agr;&ngr;&bgr;3 antagonistic activity

Phenylpiperazine derivatives as integrin &agr;v&bgr;3 antagonists

An X-ray-intercepting gold complex of mono-L-aspartyl (or mono-L-glutamyl) chlorin e6 or a salt thereof is used in the therapy of the tumor, cancer or arteriosclerosis lesions by X-ray irradiation. The complex provides a sharp x-ray image of tumor, solid cancer or lesions of arteriosclerosis. A similar platinum complex may also be utilized.

X-ray intercepting metal complexes of chlorin derivatives

D-.beta.-lysylmethanediamine derivatives and preparation thereof

As new dibekacin derivatives and new arbekacin derivatives are now provided 2'-amino-2'-deoxydibekacin, 2'-amino-5,2'-dideoxydibekacin, 2'-amino-2'-deoxyarbekacin, 2'-amino-5,2'-dideoxyarbekacin, 2'-amino-5,2'-dideoxy-5-epi-fluoroarbekacin and 2'-amino-5,2'-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.

Dibekacin derivatives and arbekacin derivatives active against resistant

16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms; and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.

16-membered macrolide derivatives and process for producing the same

Benanomicin A and Benanomicin B are fermentatively produced by the cultivation of a new microorganism Actinomadura spadix, designated as MH193-16F4 strain.

Process for the simultaneous production of benanomicins A and B

A method of producing a 3-deacylated derivative of a 16-membered macrolide antibiotic using a microorganism belonging to the genus Phialophora or Preussia which comprises incubating said microorganism with a 16-membered macrolide antibiotic in a medium containing nutritional sources commonly used for incubating microorganisms, isolating a 3-deacylated derivative from the incubation medium, a microorganism to be used for the above method and a novel macrolide antibiotic.

Process for producing 3-deacylated derivative of 16-membered macrolide

Two new antibiotics which are now nominated as benanomicin A and benanomicin B, respectively, are fermentatively produced by the cultivation of a new microorganism, designated as MH193-16F4 strain, of Actinomycetes. Benanomicins A and B each show antifungal activity and are useful as a therapeutic antifungal agent. A new compound, dexylosylbenanomicin B is now produced by chemical conversion of benanomicin B, and this semi-synthetic antibiotic also shows antifungal activity and is useful as a therapeutic antifungal agent.

Antibiotics, dexylosylbenanomicin B

As a new compound is now provided N-acetylbenanomicin B which is useful as an antifungal agent and also as antiviral agent for inhibiting infection of human T-cell with HIV, namely a virus causative of acquired human immunodeficiency syndrome. N-acetylbenanomicin B may be prepared by acetylation of 4'-amino group of benanomicin B which is fermentatively produced by a new microorganism, MH193-16F4 strain of actinomycetes.

Antibiotic N-acetylbenanomicin B, and the production and uses thereof

Benanomicins A and antibiotic compositions

Growing community of inventors

Tokyo, Japan

Shuichi Gomi