Academia Sinica

Other

National Taiwan University

Institute of Nuclear Energy Research

National Defense Medical Center

Taiwan Innovative Integration Services Co., Ltd.

Shui-Tein Chen

Chi-Huey Wong

Chun-Hung Lin

Chun-Cheng Lin

Hong-Sen Chen

Kay-Hooi Khoo

Yuan-Yuan Wang

Yow-Fu Tsai

Chun-Ming Huang

Ann Chen

Shuk-Man Ka

Kuo-Feng Hua

Lie-Hang Shen

Weir-Torn Jiaang

Te-Wei Lee

Yu-Chun Chen

Shyh-Yi Chyi

Zei-Tsan Tsai

Shiang-Rong Chang

Kuo-Ping Chao

Gann Ting

Ying-Ta Wu

Tian-Fu Huang

Chang-Mau Shing

Chong-Jen Yu

Kung-Tsung Wang

Potprommanee Laddawan

Jung-Feng Hsieh

Haou-Tzong Ma

I-Shu Lee

Ping-Hui Tseng

Ting-Fang Lo

Min-Jen Tseng

Wei-Chung Tsai

Boonyaras Sookkheo

The present disclosure disclosed herein a recombinant antibody or the antigen-binding fragment thereof which specifically binds GM2-activator protein (GM2AP). The recombinant antibody or the antigen-binding fragment thereof comprises a light chain variable region (LCVR) comprising three light chain complementary determining regions (LCDR1-3) amino acid sequences and a heavy chain variable region (HCVR) comprising three heavy chain complementary determining regions (HCDR1-3) set forth in the sequences disclosed in the embodiments of the present application. Polynucleotides encoding the same, vectors, host cells, kits and methods for detecting GM2AP and methods for inducing these recombinant antibodies or the antigen-binding fragment thereof are also provided.

Anti-GM2AP antibody and applications thereof

The present invention relates to a lung cancer biomarker for diagnosing early stage lung cancers or predicting prognosis of lung cancers, which comprises a GM2AP protein. The present invention also relates to a method for diagnosing early stage lung cancers or predicting prognosis of lung cancers in vitro by detection of the biomarker.

Lung cancer biomarker

Methods of inhibiting a phosphodiesterase (PDE) 7 enzyme such as PDE7A1 and methods for treating diseases associated with PDE7 using one or more trans-aconitic acid compounds, which can be isolated from plants.

Trans-aconitic acid compounds and uses thereof for inhibiting phosphodiesterase 7

The present invention relates to a pharmaceutical composition for treating liver diseases, comprising a miRNA mimic containing a single strand RNA molecule of hsa-miR-21-3p (SEQ ID No: 35). The miRNA mimic of the present invention can be used to treat liver diseases through regulating the expression of methionine adenosyltransferase 2A and 2B (MAT2A and MAT2B), acetyl-CoA carboxylase 1 and 2 (ACACA and ACACB), diglyceride acyltransferase 2 (DGAT2), and so on. In addition, the present invention also relates to a method for reducing the expression of the above-mentioned enzymes.

Pharmaceutical composition for treating liver diseases

The present invention relates to a new use of a cinnamaldehyde derivative of formula (I) for treating glomerulonephritis (GN). Particularly, the present invention discloses that the cinnamaldehyde derivative of formula (I) is effective in treating glomerulonephritis (GN), which can alleviate various symptoms and signs of GN, including reducing proteinuria, serum blood urea nitrogen (BUN), glomerular cell proliferation, and renal macrophage/lymphocyte infiltration, etc.

Use of hydroxycinnamaldehyde glycoside derivatives for treating glomerulonephritis

Method of treating hypertension with a trans-aconitic acid containing composition (e.g., a water extract derived from a monocotyledon plant).

Aqueous extracts from monocotyledon plants and their use in cardioprotection

The present invention provides methods of modulating an immune response in an organism by administering medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of

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The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.

Immuno-modulating antitumor activities of ganoderma lucidum (reishi) polysaccharides

The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.

A conjugate of somatostatin-spacer-drug and a method of making the same. The conjugate can be used to enhance an anti-cancer drug's specificity on the targeted tumor cells, thus increasing its therapeutic efficacy while reducing side-effects.

Use of somatostatin analogs for the delivery of anti-tumor drugs to tumor cells

The present invention provides a novel method of synthesizing branched galactose-terminal glycoproteins. A number of these glycoproteins have binding affinity to the asialoglycoprotein receptor. The present invention also provides novel conjugates having branched galactose-terminal glycoproteins that is complexed to a therapeutically effective agent, such as an isolated protein, polysacharides, lipids and radioactive isotope. These conjugates may be used to deliver the therapeutically effective agent to mammalian cells generally, and to hepatocytes specifically.

Anti liver disease drug R-YEEE and method of synthesizing branched galactose-terminal glycoproteins

A process for producing L-homophenylalanine comprises the step of reacting 2-oxo-4-phenylbutyric acid with a L-amino acid in the presence of tyrosine aminotransferase in a reaction solution to produce L-homophenylalanine.

Facile synthesis of L-homophenylalanine by equilibrium shift enzymatic

This invention is a novel synthesis of BCA-peptides (BCA: bifunctional chelating agents). In this method, the starting material--Fmoc-Thr(ol)-Terephthal-Acetal-Amide Resin is coupled with the various amino acids. The straight peptide-resin of D-Phe-Cys(Trt)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)-Terephtha l-Acetal-Amide Resin was obtained. This compound reacted with iodine to give disulfide-containing peptide resin of ##STR1## Cleavage of the peptide from the resin was achieved by TFA. The cleavaged peptide was protected by the reaction of octreotide with di-t-butyldicarbonate. BCA was coupled to the selectively protected octreotide. This product was obtained by reaction of protected BCA-peptides with TFA. The final product was labeled by radioisotope .sup.111 InCl.sub.3 for tumor imaging radiopharmaceuticals.

Method for synthesis of bifunctional chelating agents-peptides

Growing community of inventors

Taipei, Taiwan

Shui-Tein Chen