Gunze Limited

Tokyo University of Agriculture and Technology

Nippon Medical School Foundation

Shuhei Tara

Toshiharu Shinoka

Hidetaka Nakayama

Kosuke Sawai

Hirotsugu Kurobe

Eri Koyanagi

Chiemi Sakata

Tadahisa Sugiura

Yasumoto Nakazawa

There is provided a porous body which has a first surface and a second surface opposite to each other, and which comprises a first polymer material and a second polymer material, in which a Young's modulus of the first polymer material is lower than a Young's modulus of the second polymer material, an in vivo disappearance rate of the first polymer material is higher than an in vivo disappearance rate of the second polymer material, and a composition in a first region of the porous body and a composition in a second region of the porous body are different from each other.

Porous body and material for medical use

The present invention aims to provide a method for producing a porous substrate containing a bioabsorbable polymer and heparin in a simple manner without use of a surfactant, a porous substrate containing a bioabsorbable polymer and heparin, and an artificial blood vessel. The present invention provides a method for producing a porous substrate containing a bioabsorbable polymer and heparin, including: a solution preparing step of preparing a heparin-bioabsorbable polymer solution having heparin uniformly dispersed therein and a bioabsorbable polymer dissolved therein, using the bioabsorbable polymer, the heparin, a solvent 1 that is a poor solvent having a lower solvency for the bioabsorbable polymer, a solvent 2 that is a good solvent having a higher solvency for the bioabsorbable polymer and is incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2; a precipitating step of cooling the heparin-bioabsorbable polymer solution to precipitate a porous body containing the bioabsorbable polymer and the heparin; and a freeze-drying step of freeze-drying the porous body containing the bioabsorbable polymer and the heparin to provide a porous substrate containing the heparin.

Method for producing porous substrate comprising bioabsorbable polymer that contains heparin, porous substrate comprising bioabsorbable polymer that contains heparin, and artificial blood vessel

The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. The present invention relates a porous, tubular artificial blood vessel containing a bioabsorbable material, the artificial blood vessel including: a skin layer having a relatively small pore size as an innermost layer; and a porous layer positioned around the skin layer and having a relatively large pore size.

Artificial blood vessel, method for producing artificial blood vessel, and method for producing porous tissue regeneration substrate

Growing community of inventors

Tokyo, Japan

Shuhei Tara