Fujifilm Corporation

Shuhei Osaka

Makoto Ando

Daisuke Terada

Hiyoku Nakata

Takuya Matsumoto

Kyoko Senga

Hiroki Tanisaka

Yohei Kubo

Hidehiko Tanaka

Tatsuya Nitabaru

Provided is a pharmaceutical composition which contains fulvestrant in an amount of equal to or greater than 8% by mass with respect to the entire mass of the pharmaceutical composition, an aqueous solvent satisfying (1) to (4), and a pharmaceutically acceptable nonaqueous carrier satisfying (A) and (B). (1) Ethanol is contained in an amount of equal to or greater than 8% by mass with respect to the entire mass of the pharmaceutical composition. (2) At least one kind of polyhydric alcohol selected from propylene glycol or 1,3-butylene glycol is contained in an amount of equal to or greater than 3% by mass with respect to the entire mass of the pharmaceutical composition. (3) A content of benzyl alcohol is less than 5% by mass with respect to the entire mass of the pharmaceutical composition. (4) A content of the aqueous solvent is 15% to 50% by mass with respect to the entire mass of the pharmaceutical composition. (A) A content of benzyl benzoate is less than 1% by mass with respect to the entire mass of the pharmaceutical composition. (B) A content of the nonaqueous carrier is 40% to 75% by mass with respect to the entire mass of the pharmaceutical composition.

Pharmaceutical composition

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof  (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Zrepresents CH or the like; Zrepresents CRor the like; Rrepresents a hydrogen atom or the like; Xrepresents CHRor the like; Rrepresents a hydrogen atom or the like; Xrepresents CHor the like; Rand Rare the same as or different from each other, and each of Rand Rrepresents a hydrogen atom or the like; R, R, and Rare the same as or different from each other, and each of R, R, and Rrepresents a hydrogen atom, NRR, or the like; and each of Rand Rrepresents a hydrogen atom, a Calkyl group which may have a substituent, or the like).

Morpholine derivative or salt thereof

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Kanagawa, Japan

Shuhei Osaka