Massachusetts Institute of Technology

Versitech, Inc.

Other

Avalon Globocare Corp.

Avalong Globocare Corp.

Advanced Refining Technologies LLC

Shuguang Zhang

Alexander Rich

Andreas Mershin

Curtis A Lockshin

Todd Holmes

Karolina Corin

Rutledge Ellis-Behnke

Gerald E Schneider

Yael Gregory Maguire

Kwok-Fai So

David Kong

Yu-Xiang Liang

John J Schwartz

Uwe Sleytr

Joseph M Jacobson

Asmamaw T Wassie

Patrick J Moran

Carlos Semino

George M Whitesides

Akihiro Horii

Theodorus Ludovicus Michael Maesen

Rui Qing

Brian Cook

C Michael DiPersio

David Jin

David Tay

Yoshiyuki Kumada

Lotta T Tegler

Elsa Genove

Sylvain Vauthey

Kimberly Hamad

Liselotte Kaiser

Lin Yan

Cecelia A Radlowski

Dai Ohnishi

Yoshikatsu Miura

Jifei Jia

Alan J Grodzinsky

Manu Prakash

Gill M Malick

Bruno C Nesci

Daisuke Niwa

Colleen T Miedona

Xianghua Yu

David K C Tay

Henry Saternus

Atsushi Tazuke

Johanna F Graveland-Bikker

Sotirios Koutsopoulos

Fei Tao

Johanna F Bikker

Andreas Breitwieser

Xiumei Wang

Fabrizio Gelain

John Kisiday

Lotta Tolstoy Tegler

Theodorus Ludovicus Maesen

Alan Grodzinsky

Gerald Schneider

David KC Tay

David Flat F 10F Block 2 Tay

Yu-Xiang 1/F Laboratory Block Liang

The present invention is directed to QTY CCR9 and CXCR2 variant Fc receptor fusion proteins, methods for the preparation thereof and methods of use thereof.

QTY Fc fusion receptor proteins

Compositions that include nanoscale structured materials or precursors thereof (e.g., self: assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.

Compositions and methods for promoting hemostasis and other physiological activities

The present invention is directed to QTY Fc receptor fusion proteins, methods for the preparation thereof and methods of use thereof.

QTY FC fusion water soluble receptor proteins

QTY FC fusion receptor proteins

The invention includes a bioelectronic interface comprising a self-assembling unit, wherein the self-assembling unit comprises a variant GPCR fusion protein bound to an S-layer fusion protein. The invention also encompasses a biosensor or device comprising the bioelectronic interface and methods of screening for a ligand of a GPCR.

S-layer protein 2D lattice coupled detergent-free GPCR bioelectronic interfaces, devices, and methods for the use thereof

The present invention is directed to a computer implemented method for executing a procedure to select a water-soluble variant of a G Protein-Coupled Receptor (GPCR).

Water-soluble trans-membrane proteins and methods for the preparation and use thereof

The present invention is directed to a method of preparing a water-soluble variant of a G-protein coupled receptor (GPCR), the method comprising replacing residues leucine (L), isoleucine (I), valine (V), and phenylalanine (F) in hydrophilic surface &#x3b1;-helical positions b, c, and f but not positions a, d, e, and g within the-transmembrane &#x3b1;-helical domain of the GPCR with glutamine (Q), threonine (T), threonine (T), and tyrosine (Y), respectively.

Water soluble membrane proteins and methods for the preparation and use thereof

The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor&#x2014;the olfactory receptor&#x2014;on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor&#x2014;the olfactory receptor&#x2014;immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

Bio-sensing nanodevice

The invention relates to a pharmaceutical formulation for sustained delivery of a therapeutic agent, preferably a protein, polypeptide, an antibody or an antibody fragment, comprising one or more gel forming peptides wherein the formulation exhibits sustained delivery for at least two weeks, three weeks, four weeks, five weeks, six weeks, seven weeks, eight weeks, nine weeks, ten weeks, eleven weeks, twelve weeks or more. In one embodiment, the invention relates to a formulation comprising self-assembling peptides that undergo sol-gel transition in the presence of an electrolyte solution such as biological fluids and salts. The formulation can provide sustained release of antibody and antibody fragments, in particular, IgG. Antibody diffusivities can be decreased with increasing hydrogel nanofiber density, providing a means to control the release kinetics.

Multi-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies

The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the production of extracellular matrix proteins, and methods of treatment comprising administering self-assembling peptides.

Self-assembling peptides incorporating modifications and methods of use thereof

In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this scent matching even in a changing olfactory environment, and even if the positive control scent is a combination of hundreds or thousands of different odorants. No prior training is needed, and no attempt is made to identify a single odorant that is unambiguously responsible for a scent. Instead, a computer compares the total scent pattern of a positive control sample with the total scent pattern of a test sample, across a sweep of many permutations of electrical inputs to scent sensors, to try to find any condition under which the total scent patterns do not match. If such a condition cannot be found, then the computer declares a match between the test and target scents.

Methods and apparatus for artificial olfaction

Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.

The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.

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Lexington, MA, United States of America

Shuguang Zhang