Virginia Tech Intellectual Properties, Inc.

Harvard College

Children's Medical Center Corporation

Cyt Immune Sciences, Inc.

Shugeng Cao

David G I Kingston

Jon Clardy

Paula I Watnick

Marja S Huhta

Patrick Ymele-Leki

Jielu Zhao

Glullo F Paciotti

Marja S Hubta

Mathis Hodge

Provided herein are pure and isolated natural products and analogs thereof of Formula (I), (II), (III), and (IV), pharmaceutical compositions thereof, and methods of use, for example, for treating a bacterial infection. Further provided are methods useful in identifying an inhibitor of bacterial sugar fermentation in a bacterial strain, such as a compound (inhibitor) of Formula (I), (II), (III), or (IV): or a pharmaceutically acceptable salt thereof.

Natural product antibiotics and analogs thereof

Thioloated taxane derivatives are linked to colloidal metal particles such as gold nanoparticles for use as antitumor agents. The antitumor agents may be targeted to tumors.

Thiolated paclitaxels for reaction with gold nanoparticles as drug delivery agents

Ipomoeassin compounds derived from morning glory plant material (especiallysp. from Suriname) are useful as anti-cancer agents. The novel compounds also are useful for treating neurodegenerative disorders (such as Alzheimer's disease) in human patients.

Morning glory-derived anticancer agents, and novel ipomoeassin compounds

Growing community of inventors

Waltham, MA, United States of America

Shugeng Cao