Agency for Science, Technology and Research

Zhejiang University

Haining Zhuluoji Biotechnology Co., Ltd.

Shufang Zhang

Yi Hong

Hongwei Ouyang

Feifei Zhou

Hanry Yu

Hwa Liang Leo

Renjie Liang

Yiwei Zou

Oikai Li

An integrally-formed three-dimensional (3D) bio-printing system capable of alternate feeding of multiple materials, comprising: an optical imaging unit and a light path conversion unit, wherein the optical imaging unit comprises an image processing unit and a projection unit, the image processing unit segmenting a 3D modeling graphic of a printed subject to form image information, the projection unit converting the image information into one or more optical images, and the light path conversion unit projects the imaged light paths into bio-ink that can be cured by light, so that the projected image can cure the bio-ink by means of the focus of light.

Imaging principle-based integrated color light 3D bioprinting system

The purpose of the present invention is to provide a light control agent and explore its application, and is expected to improve the tissue binding force and convenience of the existing biological glue material by providing a new reagent or material for biological damage or homeostasis. In one of embodiment, this invention provides an agent for repairing biological damage or homeostasis, wherein the agent comprises a natural biological macromolecule modified by the photo-responsive cross-linking group.

Agent for biological damage repair or hemostasis and the method thereof

The apparatus for cell or tissue culture comprises a base plate (), an intermediate face () and a top plate (). The intermediate face () is removably sandwiched between the base plate () and the top plate (). The base plate () has a circumferential wall (), a base () and a top wall (). The top wall () of the base plate () comprises a plurality of recesses () arranged in n lines, wherein n is an integer from 1 to about 25. Each line of recesses () ranges from a first recess to a last recess. Each recess has a circumferential recess wall (), which has one recess inlet and one recess outlet (). The circumferential wall () comprises a number of 2 n ports (). Each port () is coupled to a single line of recesses (). The recesses () of each line of recesses are in fluid communication with (i) each other via the recess inlets and a recess outlets () and (ii) with a first and a second port () of the 2 n ports, such that the first recess of each line of recesses is coupled to a first port and the last recess of each line of recesses is coupled to a second port. The intermediate face () has a plurality of recesses () arranged in m lines, fitted into the plurality of recesses () of the top wall () of the base plate (). m is an integer from 1 to about 25 equal to or smaller than n. The recesses () of the intermediate face () have water permeability. The top plate () is reversibly sealed to the intermediate face () and the intermediate face () is reversibly sealed to the base plate (). Thus the recesses () of the top wall () of the base plate () define culture chambers. Each culture chamber has a circumferential wall defined by the recess wall () and a removable top, which is defined by a portion of the top plate ().

Apparatus for cell or tissue culture

Growing community of inventors

Hangzhou, China

Shufang Zhang