Yangtze River Pharmaceutical Group Co., Ltd.

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

Shanghai Jemincare Pharmaceuticals Co., Ltd.

Jiangxi Jemincare Group Co., Ltd.

Shuchun Guo

Jiong Lan

Haibing Guo

Fusheng Zhou

Jianbiao Peng

Jinzhu Zhao

Yang Liu

Kai Zhang

Jing Xie

Xiang Chen

Dong Huang

Wan He

Changjiang Qiao

Hui Li

Qiong Zhang

Hui Xu

Jun Fan

Yi Hu

Yufeng Li

Fang Bao

Jiangwei Wang

Shan Yao

Zhangping Kang

Yan Ye

Xia Shi

Yong Zhang

Xi Chen

Disclosed in the present invention are a fused pyridone compound, and a preparation method therefor and a use thereof. Specifically, the present invention discloses a compound of formula (I-B), an optical isomer thereof and a pharmaceutically acceptable salt thereof, and the use of the compound as a KRAS inhibitor.

Fused pyridone compound, and preparation method therefor and use thereof

A compound represented by formula (I), an optical isomer thereof and a pharmaceutically acceptable salt thereof, as well as an application of said compound as an FXIa inhibitor. 

Tricyclic compound, preparation method therefor and use thereof

Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist. 

Cyclic dinucleotide compound and uses thereof

The present invention relates to a 1,2-dihydropyrrol[3,4-c]pyridin/pyrimidin-3-one derivative substituted by N-(3-aminophenyl)acrylamide and a preparation method and pharmaceutical use thereof. In particular, the present invention relates to a compound of formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof and a preparation method and application of the same. The definition of each substituent in the formula is described in detail in the specification and claims. 

Aniline-substituted 1,2-dihydropyrrol[3,4-C]pyridin/pyrimidin-3-one derivative and use thereof

The present disclosure relates to 4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives, and their preparations and medicinal use. Specifically, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof, wherein the definition of each group is as described in the specification and claims. 

4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives and uses thereof

It is provided herein a benzobicycloalkane derivative, and a preparation method and use thereof. In particular, it is provided herein a compound of Formula (I), or a pharmaceutically acceptable salt, stereoisomer or solvate thereof, a preparation method, and a use thereof in preparation of drugs for treating pain. 

Benzobicycloalkane derivatives, their preparation and pharmaceutical use thereof

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Shanghai, China

Shuchun Guo