Mayo Foundation for Medical Education and Research

University of Minnesota

Shuchong Pan

Robert D Simari

John C Burnett, Jr

Horng H Chen

Lincoln R Potter

Jr John C Burnett

This document provides diuretic and natriuretic polypeptides. For example, this document provides polypeptides having diuretic and/or natriuretic activities. In some cases, a polypeptide provided herein can have diuretic and natriuretic activities, while lacking the ability to lower blood pressure. This document also provides methods and materials for inducing diuretic and/or natriuretic activities within a mammal.

Methods of treatment of heart dysfunctions using diuretic and natriuretic polypeptides

Method of treatment of renal dysfunctions with chimeric natriuretic peptides

Methods and materials for diagnosing and treating heart conditions (e.g., heart failure) and kidney conditions (e.g., kidney failure) are described.

Method for increasing natriuresis or diuresis by isoforms of brain natriuretic peptide

This document relates to methods and materials involved in preferentially activating natriuretic peptide receptor-C polypeptides. For example, agonists of natriuretic peptide receptor-C polypeptides as well as methods for activating natriuretic peptide receptor-C polypeptides are provided herein.

Natriuretic peptide receptor-C agonists

Isoforms of brain natriuretic peptide

Diuretic and natriuretic polypeptides lacking the blood pressure lowering property

Growing community of inventors

Rochester, MN, United States of America

Shuchong Pan