Michigan State University

Other

Resverlogix Corporation

Shubham P Chopade

Dennis J Miller

James E Jackson

Angela M Clark

Christopher W Kiesling

Atulkumar D Dhale

John G Frye

Todd A Werpy

Alan H Zacher

Henrik C Hansen

George Yiannikouros

Janakiram Rao Citineni

Robert P Short

George P Yiannikouros

Janakiram R Citineni

The present disclosure relates to methods for preparing compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and in the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis. 

Methods of preparing quinazolinone derivatives

A process for the separation of a polyol or multiple polyols in admixture with other organic compounds, usually those produced with the polyol, is described. The process uses a distillation in a column ( ) of a cyclic acetal from an aqueous solution which acetal is formed in a reaction mixture of the polyol and an aldehyde or ketone. The polyols, such as ethylene glycol and propylene glycol, are staple articles of commerce with many uses.

Process for the recovery of a polyol from an aqueous solution

The present invention provides a process for preparation of low molecular weight polyols from high molecular weight polyols in a hydrogenolysis reaction under elevated temperature and hydrogen pressure. The process comprises providing in a reaction mixture the polyols, a base, and a metal catalyst prepared by depositing a transition metal salt on an inert support, reducing the metal salt to the metal with hydrogen, and passivating the metal with oxygen, and wherein the catalyst is reduced with hydrogen prior to the reaction. In particular, the process provides for the preparation of glycerol, propylene glycol, and ethylene glycol from sugar alcohols such as sorbitol or xylitol. In a preferred process, the metal catalyst comprises ruthenium which is deposited on an alumina, titania, or carbon support, and the dispersion of the ruthenium on the support increases during the hydrogenolysis reaction.

Catalysts and process for hydrogenolysis of sugar alcohols to polyols

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Florence, SC, United States of America

Shubham P Chopade