Novartis Ag

Shuangxi Wang

Ritesh Bhanudasji Tichkule

Chandra Vargeese

Rohan Eric John Beckwith

Thomas Zabawa

Gabriel Grant Gamber

Jeremy Lee Baryza

Junping Zhao

Cameron Chuck-munn Lee

Tanzina Fazal

Laura Ellen West

Crystal Byers

Gang Liu

Muneto Mogi

Keith Jendza

Erik Meredith

Rajesh Karki

Atwood Kim Cheung

Rui Zheng

Vivek Rauniyar

Chun Zhang

Daniela Angst

Justin Yik Ching Mao

Liansheng Su

Liang Zhao

Philippe Bolduc

Viktor Hornak

Xiang Gao

Véronique Darsigny

Jeffrey M McKENNA

Matthew William Carson

Ajay Kumar Lal

Cameron Chuck-Munn Lee

The disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof wherein A, Rto R, and Rto R, are as described herein, as well as compositions and methods of using such compounds.

Hydroquinazoline derivatives for the treatment of a disease or disorder

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

Lipids and lipid compositions for the delivery of active agents

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R-R, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

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Cambridge, MA, United States of America

Shuangxi Wang