Beijing Beikehuaxia Bio-medical Technology Co., Ltd.

Guangzhou Liushun Biotechnology Co., Ltd.

Shuang Xie

Yan Wang

Jin Ma

Bing Liu

Xueqi Qian

Nengan Chen

Daping Li

Jingsi Dai

Xihong Liu

Junjun Dong

Lianwu Deng

A multi-target kinase inhibitor is shown in formula (I), in which R is selected from formula (a), formula (b), formula (c), formula (d), formula (e) and formula (f). The multi-target kinase inhibitor can effectively inhibit the enzymatic activities of RET, VEGFR3 and PDGFRA, and can effectively treat diseases that are regulated and controlled by multi-target kinases and are related to abnormal signal transduction pathways of the multi-target kinases, including cancers of breast, respiratory tract, brain, reproductive organ, digestive tract, urinary tract, eye, liver, skin, head and/or neck and distant metastatic cancers thereof, and lymphoma, sarcoma, leukemia and the like. The active ingredients of the pharmaceutical composition of the present invention comprise a multi-target kinase inhibitor, which accounts for 1-50 wt % of the composition.

Multi-target kinase inhibitor, pharmaceutical composition, and preparation method for multi-target kinase inhibitor and use thereof

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Guangdong, China

Shuang Xie