Qualcomm Incorporated

Chinese Academy of Sciences

Zhengzhou Gensciences Inc.

Shanghai Saiyuan Bio-technology Co., Ltd.

Shuang Wang

Jing Li

Wei Wei

Yali Wang

Yu Wang

Chang Zhang

Guanghui Ma

Haojun Wang

Xian Chen

Bing Leng

Jiuru Sun

Zijia Ren

Wenwen Wang

Qilei Wang

Shuang Qing

Shuya Wang

Jie Gao

Tiejiong Fan

Luyan Zhu

Hongsheng Su

Xiaoshan Wang

Lingli Huang

Haitao Hu

Lili Zhang

Chunfeng Xiao

Zhiwei Sun

Jianghua Wang

Weiyi Qiu

Disclosed are a coagulation factor VIII fusion protein which is conjugated with polyalkylene glycol and which has an extended cyclic half-life, a preparation method therefor and a use thereof, wherein the active moiety of the coagulation factor VIII is directly linked or indirectly linked by a peptide linker to a fusion partner, and the fusion protein is further conjugated to a polyalkylene glycol. The half-life is significantly increased compared to an FVIII fusion protein modified without polyalkylene glycol.

FVIII fusion protein and use thereof

Provided is an exosome, which is secreted by a hybrid cell formed by antigen-presenting cells phagocytosing the cell nuclei of tumor cells. Using the strategy of macrophages phagocytosing the cell nuclei of tumor cells achieves endogenous expression of tumor antigens on macrophages, and the exosome prepared has good capabilities of targeting to lymph nodes and tumors dually.

Method of making exosomes from tumor cell/antigen presenting cell hybrid cells

A user equipment (UE) may determine that a condition associated with a first radio access technology (RAT) is satisfied. The UE may select a cell, from a list of anchor cells associated with a second RAT and configured for dual-connectivity, for a connection based at least in part on the determination that the condition associated with the first RAT is satisfied. The UE may establish the connection with the selected cell. Numerous other aspects are provided.

Techniques for cell selection for dual-connectivity

Growing community of inventors

Beijing, China

Shuang Wang